皮质酮对吗啡急性精神运动兴奋性及行为敏感化的影响
Effect of Corticosterone on Morphine-induced Psychomotor Effect and Its Sensitization
查看参考文献12篇
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文摘
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目的:考察皮质酮对吗啡急性精神运动兴奋性和行为敏感化的作用.方法:32只SD大鼠分为四组,腹腔分别给予生理盐水(1ml/kg)、吗啡(2mg/kg)、皮质酮(5mg/kg)、皮质酮/吗啡后,计算机自动记录60分钟大鼠的水平活动量,作为急性精神运动的测量指标.每两天重复测量一次,实验进行14天,七次的水平运动作为行为敏感化的指标.结果:皮质酮/吗啡组表现出明显的精神运动兴奋性(盐水组7175±676,皮质酮/吗啡组10365±503,P＜0.05).对行为敏感化效应而言,吗啡组和皮质酮/吗啡组都形成了明显的行为敏感化(F(6,156)=2.41,P＜0.05;F(6,156)=4.27,P＜0.01),但组别和时间的交互作用不显著(F(6,78)=1.018,P=0.420),表明皮质酮对吗啡的行为敏感化没有影响.结论:皮质酮增强吗啡的精神运动兴奋性但不影响行为敏感化现象 |
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其他语种文摘
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To explore the role of corticosterone in morphine - induced acute psychomotor activity and behavioral sensitization. Methods: 32 male SD rats were divided into four groups. Rats were intraperitoneally given saline, morphine, corticosterone and corticosterone/morphine separately. The horizontal locomotor activity was recorded for 60min by the computer trace system automatically. The locomotor activity was measured in every two days for total seven times. Results j The corticosterone/moiphine group showed significant morphine - induced acute psychomotor effect comparing with the saline group (saline group 7175 ± 676, corticosterone/morphine group 10365 ± 503, P < 0. 05) . In behavior sensitization, the morphine group and the corticosterone/morphine group showed significant behavioral sensitization (P<0.05), but the interaction of Group x Time is not significant ( F (6,78) =1.018, P = 0.420) , so the corticosterone had no effect on morphine - induced behavioral sensitization. Conclusion; Corticosterone increased the morphine -induced acute psychomotor activity but did not modify the behavioral sensitization induced by repeated morphine injection. |
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来源
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中国心理卫生杂志
,2006,20(1):32-34 【核心库】
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关键词
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药物成瘾
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动物研究
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吗啡
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精神运动性
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敏感化
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地址
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中科院心理健康研究室, 北京, 100101
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语种
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中文 |
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文献类型
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研究性论文 |
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ISSN
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1000-6729 |
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学科
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社会科学总论 |
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基金
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国家973计划
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国家自然科学基金重点项目
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中国科学院知识创新工程项目
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文献收藏号
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CSCD:2240011
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参考文献 共
12
共1页
|
|
1.
Goeders NE. The impact of stress on addiction.
Eur Neuropsy-chopharmacol,2003,13(6):435-441
|
被引
4
次
|
|
|
|
|
2.
Deroche V. Repeated corticos terone administration sensitizes the locomotor response to am phetamine.
Brain Res,1992,584(1/2):309-13
|
被引
1
次
|
|
|
|
|
3.
Deroche V. Stress-induced sen-sitization and glucocorticoids.
J Neurosc,1995,15(11):7181-7188
|
被引
1
次
|
|
|
|
|
4.
Vanderschuren LJ. Morphine-in duced long-term sensitization to the locomotor effects of mor phine and amphetamine depends on the temporal pattern of the pretreatment regimen.
Psychopharmacology (Berl),1997,131(2):115-22
|
被引
3
次
|
|
|
|
|
5.
Deroche V. Stress-induced sensi-tization to amphetamine and morphine psychomotor effects depend on stress-induced corticosterone secretion.
Brain Res,1992,598(1/2):343-8
|
被引
2
次
|
|
|
|
|
6.
Marinelli M. Glucocorticoids and behavioral effects of psychostimulants.
J Pharmacol Exp Ther,1997,281(3):1392-1400
|
被引
2
次
|
|
|
|
|
7.
Prasad BM. Sensitization to stress and psychostimulants.
Ann N Y Acad Sci,1995,771:617-625
|
被引
1
次
|
|
|
|
|
8.
de Jong IE. toward substrate and mechanism.
Ann N Y Acad Sci,2004,1018:192-198
|
被引
2
次
|
|
|
|
|
9.
Zarrindast MR. sensitization and interactions with dopamine receptors.
Eur J Pharmacol,2004,497(2):197-204
|
被引
3
次
|
|
|
|
|
10.
Rivet JM. Behavioral sensitization to amphetamine is dependent on corticosterone receptor acti vation.
Brain Res,1989,498(1):149-153
|
被引
2
次
|
|
|
|
|
11.
Badiani A. Circulating adrenal hor-mones are not necessary for the development of sensitization to the psychomotor activating effects of amphetamine.
Brain Res,1995,673(1):13-24
|
被引
2
次
|
|
|
|
|
12.
Prasad BM. Effect of adrena lec-tomy on the initiation and expression of cocaine-induced sen-sitization.
Psychopharmacology (Berl),1996,125(3):265-73
|
被引
1
次
|
|
|
|
|
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