Phase II metabolites of etofesalamide in filamentous fungi
查看参考文献15篇
|
文摘
|
To study phase II metabolites of etofesalamide in filamentous fungi. Methods: Seven fungi were screened to transform etofesalamide. The metabolites of etofesalamide were assayed using liquid chromatography coupled to mass spectrometry. The major metabolite was subject to enzymatic hydrolysis to confirm its structure. Results: Etofesalamide was converted into two phase II metabolites: glucoside and riboside conjugates. Glucoside conjugate was the major product with a yield greater than 90%; no phase I metabolites were detected. Conclusion: Glucoside and riboside conjugations of etofesalamide in filamentous fungi differ from the phase II metabolism of glucuronidation in mammals. |
|
来源
|
Acta Pharmacologica Sinica
,2005,26(7):893-896 【核心库】
|
|
DOI
|
10.1111/j.1745-7254.2005.00091.x
|
|
关键词
|
etofesalamide
;
Cunninghamella
;
metabolite
;
transformation
;
mass spectrum analysis
|
|
地址
|
1.
Department of Pharmaceutical Microbiology, Shenyang Pharmaceutical University, 辽宁, Shenyang, 110016
2.
Laboratory of Drug Metabolism and Pharmacokinetics, Shenyang Pharmaceutical University, 辽宁, Shenyang, 110016
|
|
语种
|
英文 |
|
文献类型
|
研究性论文 |
|
ISSN
|
1671-4083 |
|
学科
|
药学 |
|
基金
|
国家863计划
|
|
文献收藏号
|
CSCD:2208856
|
参考文献 共
15
共1页
|
|
1.
Liu BL. Synthesis of etofesalamide.
Acta Pharmaceutica Sinica,1987,22:312-315
|
被引
1
次
|
|
|
|
|
2.
Zhong DF. The major metabolite of etofesalamide in rabbits.
J Shenyang Pharm Univ,1996,13:240-244
|
被引
1
次
|
|
|
|
|
3.
Chu DF. Isolation and identification of etofesalamide-2-glucuronide.
Chem J Chin Univ,2002,23:376-378
|
被引
1
次
|
|
|
|
|
4.
Srisilam K. Biotransformation of drugs by microbial cultures for predicting mammalian drug metabolism.
Biotechnol Adv,2003,21:3-39
|
被引
7
次
|
|
|
|
|
5.
Zhang DL. Phase I and phase II enzymes produced by Cunninghamella elegans for the metabolism of xenobiotics.
FEMS Microbiol Lett,1996,138:221-226
|
被引
4
次
|
|
|
|
|
6.
Zhong DF. Microbial transformation of naproxen by Cunninghamella species.
Acta Pharmacol Sin,2003,24:442-447
|
被引
9
次
|
|
|
|
|
7.
Sun L. Transformation of verapamil by Cunninghamella balkesleeama.
Appl Environ Microbiol,2004,70:2722-2727
|
被引
6
次
|
|
|
|
|
8.
Ritter JK. Roles of glucuronidation and UDP-glucuronosyl transferases in xenobiotic bioactivation reactions.
Chem Biol Interact,2000,129:171-193
|
被引
9
次
|
|
|
|
|
9.
Shipkova M. Glucuronide and glucoside conjugation of mycophenolic acid by human liver.
Br J Pharmacol,2001,132:1027-1034
|
被引
4
次
|
|
|
|
|
10.
Chen XY. formation of morphine glucosides in cancer patients.
Br J Clin Pharmacol,2006,55:570-578
|
被引
1
次
|
|
|
|
|
11.
Azerad R. Microbial models for drug metabolism.
Adv Biochem Eng Biotech,1999,63:169-218
|
被引
7
次
|
|
|
|
|
12.
Kamimura H. Conversion of zearalenone to zearalenone glycoside by Rhizopus sp.
Appl Environ Microbiol,1986,52:515-519
|
被引
4
次
|
|
|
|
|
13.
Pothuluri JV. Formation of sulfate and glucoside conjugates of benzo[e]pyrene by Cunninghamella elegans.
Appl Microbiol Biotechnol,1996,45:677-683
|
被引
3
次
|
|
|
|
|
14.
Ye M. Specific 12 beta-hydroxylation of cinobufagin by filamentous fungi.
Appl Environ Microbiol,2004,70:3521-3527
|
被引
4
次
|
|
|
|
|
15.
Gesell M. Oxidation and ring cleavage of dibenzofuran by the filamentous fungus Paecilomyces lilacinus.
Arch Microbiol,2004,182:51-59
|
被引
1
次
|
|
|
|
|
了解气象卫星更多信息，请访问