组织蛋白酶及其抑制剂研究进展
Cathepsins: Structures, Functions and Inhibitors
查看参考文献74篇
文摘
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组织蛋白酶是半胱氨酸蛋白酶家族的主要成员,在生物界已发现20余种,人体中主要存在11种,它们与人类肿瘤、骨质疏松、关节炎等多种重大疾病密切相关,是近年来备受关注的一类靶标蛋白酶.自从20世纪90年代以来,多种组织蛋白酶的晶体结构陆续明确,有关其研究进展较快.本文以人类组织蛋白酶为重点,主要介绍近15年来组织蛋白酶结构、功能和抑制剂研究方面的一些重要进展. |
其他语种文摘
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Ciilhepsins are ihe main members of ihe cysteine protease family. Up to now, more than 20 cathepsins have been discovered in living organisms including 11 kunan cathepsins, which are involved in many serious human diseases, such as tumor, osteoporosis, arthritis and so on. So cathepsins may repr-esent important drug targets with more attention. Since 1990, the ciystal structures of several cathepsins were obtained respectively, the research about them progressed much. This paper summarized recent de-velopments in structures, functions and inhibitors of cathepsins, especially human cathepsins. |
来源
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云南植物研究
,2005,27(4):337-354 【核心库】
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关键词
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组织蛋白酶
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结构
;
功能
;
抑制剂
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地址
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中国科学院昆明植物研究所, 植物化学与西部植物资源持续利用国家重点实验室, 云南, 昆明, 650204
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语种
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中文 |
文献类型
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综述型 |
ISSN
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0253-2700 |
学科
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植物学 |
基金
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中国科学院项目
;
国家863计划
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文献收藏号
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CSCD:2027122
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74
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