芳香族和脂环族化合物在反刍家畜消化道中的释放代谢机制
Metabolism of aromatic and alicylic compounds in the digestive tract of ruminants
查看参考文献53篇
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文摘
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芳香族和脂环族化合物(异生物素)在反刍动物体内的消化代谢水平主要取决于瘤胃的消化代谢能力,而这种能力是由瘤胃微生物决定的;瘤胃微生物在厌氧环境下具有降解芳香族异生物素的潜力,咀嚼有助于植物细胞壁脂化酚酸及其内容物的酚化合物的释放,释放后的代谢物大部分在瘤胃内被微生物代谢;瘤胃微生物糖酶的作用,使与细胞壁结合的酚酸以可溶性酯-糖单元的形式从牧草中释放出来,在肠道内微生物水解活动可引起植物中自然存在的结合态酚酸释放成游离态;细胞壁酯化的p-香豆酸含量与体内细胞壁消化率、体外干物质消化率和半体内瘤胃纤维降解率呈显著负相关,草本植物的木质素含量与细胞壁降解率也常为负相关;异生物素对动物和微生物具有毒害作用,但在瘤胃的厌氧微生物作用下,通过水解、还原、取代和脱羧等反应,异生物素发生生物转化和矿化,其还原代谢产物的毒性远低于其前体物.芳香族化合物在反刍家畜消化道中的释放代谢机制的研究,为其代谢物在尿液中的排泄含量作为反刍动物采食量的预测指标的可行性和机理从代谢水平上奠定基础. |
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其他语种文摘
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The level of metabolizing aromatic and alicylic compounds in ruminant body depends on the metabolizing capacity of rumen where microorganisms play an important role. Under anaerobic condition in rumen, microbial metablism is the main pathway by which xenobiotics were degraded. Aromatic xenobiotics released after mastication have three fates in the digestive tract-absorbed, bounded to unavailable proteins and lipids of the digesta leading to excretion in the faeces, and mostly metabolized in rumen by microbial activities and reactions such as hydrolysis, reduction, decarboxylation, O-dealkylation, dehydroxylation and hydrogenation. Besides, cell wall (CW) bound phenolic acids can also be released from forages as soluble esters with carbohydrates due to the action of carbohydrases from rumen microorganisms. Subsequently, the xenobiotics are partial degraded (biotransformation) and complete degraded (mineralisation) and, as a result, the toxicity become far less from their precursors. It has also found that the content of CW-esterified p-coumaric acid has significant negative correlations with CW digestibility in vivo, dry matter digestibility (DMD) in vitro and ruminal cellulose degradability (so does as the lignin content) in sacco. The review and summary of rumen metabolisation of aromatic xenobiotics provide a base for predicting feed intake of grazing ruminants according with their contents in urine. |
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来源
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草业学报
,2004,13(5):18-25 【核心库】
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关键词
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异生物素
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释放
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瘤胃微生物
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水解反应
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还原代谢
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地址
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1.
中国科学院西北高原生物研究所, 青海, 西宁, 810001
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北京师范大学环境科学学院, 北京, 100875
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甘肃农业大学草业学院, 甘肃, 兰州, 730070
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Universidad Nacional de Le Pampa, Argentina
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语种
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中文 |
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文献类型
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研究性论文 |
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ISSN
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1004-5759 |
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学科
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畜牧、动物医学、狩猎、蚕、蜂 |
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基金
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中国科学院“百人计划”项目
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国家教育部高等学校优秀青年教师教学科研奖励计划
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文献收藏号
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CSCD:1616755
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参考文献 共
53
共3页
|
|
1.
龙瑞军. 反刍动物采食量的概念与研究方法.
草业学报,2003,12(5):8-17
|
被引
28
次
|
|
|
|
|
2.
龙瑞军. 利用芳香族化合物估测反刍动物采食量的潜力.
草业学报,2004,13(2):13-22
|
被引
8
次
|
|
|
|
|
3.
Jung H G. A review[J].
Journal of Animal Science,1983,57:206-219
|
被引
5
次
|
|
|
|
|
4.
Jung H G. Interactions among phenolic monomers and in vitro fermentation[J].
Journal of Dairy Science,1983,66:1255-1263
|
被引
1
次
|
|
|
|
|
5.
Patterson J A. Rumen microbiology[A].
Encyclopedia of Microbiology (Volume 3),1992:623-642
|
被引
1
次
|
|
|
|
|
6.
Bourquin L D. Forage level and particle size effects on orchardgrass digestion by steers I Site and extent of organic matter.
Journal of Animal Science,1994,72:746-758
|
被引
2
次
|
|
|
|
|
7.
Lowry J B. Metabolic and nutritional significance of the cell-wall phenolic acid fraction[A].
Microbial and Plant Opportunities to Improve Lignocellulose Utilization by Ruminants,1990:119-126
|
被引
3
次
|
|
|
|
|
8.
Borneman W S. Ultrastructure and cell wall degrading enzymes[A].
Microbial and Plant Opportunities to Improve Lignocellulose Utilization by Ruminants,1990:325-339
|
被引
1
次
|
|
|
|
|
9.
Besle J M. Hydrolysis and degradation of esterified phenolic acids from maize cell wall by rumen microbial species[A].
Evolution of the Rumen Microbial Ecosystem, Symposium Abstracts,1997:25
|
被引
1
次
|
|
|
|
|
10.
Akin D E. p-Coumaroyl and feruloyl arabinoxylans from plant cell walls as substrates for ruminal bacteria[J].
Applied and Environmental Microbiology,1993,59:644-647
|
被引
2
次
|
|
|
|
|
11.
Gordon A J. Chemical and in vivo evaluation of a brown midrib mutant of Zea mays I fibre.
Journal of Science in Food and Agriculture,1973,24:565-577
|
被引
1
次
|
|
|
|
|
12.
Weimer P J. Microbial and molecular mechanisms of cell wall degradation - session synopsis[A].
Forage Cell Wall Structure and Digestibility,1993:485-498
|
被引
1
次
|
|
|
|
|
13.
Hartley R D. p-Coumaric and ferulic acid components of cell walls of ryegrass and their relationships with lignin and digestibility[J].
Journal of the Science of Food and Agriculture,1972,23:1347-1354
|
被引
4
次
|
|
|
|
|
14.
Ford C W. Biodegradability of mature grass cell walls in relation to chemical composition and rumen microbial activity[J].
Journal of Agricultural Science,1987,108:201-209
|
被引
1
次
|
|
|
|
|
15.
Theander O. Acetyl and phenolic acid substituents in timothy of different maturity and after digestion with rumen microorganisms or a commercial cellulase[J].
Agriculture and Environment,1981,6:127-133
|
被引
1
次
|
|
|
|
|
16.
Martin S A. Effect of phenolic compounds on fiber-degrading enzymes from rumen bacteria[A].
Microbial and Plant Opportunities to Improve Lignocellulose Utilization by Ruminants,1990:289-300
|
被引
1
次
|
|
|
|
|
17.
Fahey G C Jr. Phenolic compounds in roughages and their fate in the digestive system of sheep[J].
Journal of Animal Science,1980,50:1165-1172
|
被引
1
次
|
|
|
|
|
18.
Titgemeyer E C. Digestion of cell wall components by dairy heifers fed diets based on alfalfa and chemically treated oat hulls[J].
Journal of Dairy Science,1991,74:1026-1037
|
被引
1
次
|
|
|
|
|
19.
Grabber J H. In Vitro disappearance of carbohydrates.
Journal of the Science of Food and Agriculture,1991,57:315-323
|
被引
1
次
|
|
|
|
|
20.
Chesson A. Mechanistic models of forage cell wall degradation[A].
Forage Cell Wall Structure and Digestibility,1993:347-376
|
被引
2
次
|
|
|
|
|
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