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山西省阳城县宫颈癌危险因素研究
Analysis of Risk Factors for Cervical Cancer in Yangcheng County

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曾转萍 1   陈凤 2   刘彬 2   黄曼妮 2   张洵 2   潘秦镜 2   赵芳辉 2   戎寿德 2   乔友林 2  
文摘 目的研究影响我国宫颈癌高发区宫颈癌发生的危险因素,为宫颈癌防治工作提供依据.方法本研究建立在山西省阳城县宫颈癌筛查方法比较研究基础上,采用了横断面调查方法.所有病例都经病理组织学确诊.HPV的检测是应用第二代杂交捕获试验对妇女宫颈细胞进行检查.资料采用VFP软件进行录入和整理,利用χ2检验和非条件Logistic回归模型分析危险因素与宫颈癌的关系.结果共3233名妇女参加了本次研究,该人群HPV总检出率为30.4%,宫颈癌(宫颈高度病变以上,≥CIN3)的高危型HPV感染率为99.0%,正常为24.0%.宫颈癌患病率越高的村,HPV感染的危险度比值比越大,与<1.31组相比,1.31~3.70和>3.70组OR分别为1.14(0.94~1.37)和1.44(1.19~1.73).单因素分析与宫颈癌相关的因素有HPV感染、生产次数(1/≥3)和宫颈糜烂、息肉,OR分别为307.5(42.8~2209.2)、2.44(1.16~5.14)和1.56(1.03~2.35).多因素非条件logistic回归分析结果表明HPV感染与宫颈癌发生相关. 结论 HPV感染是宫颈癌发生的主导因素,提示宫颈癌的防治重点应放在高发区高发村高危型HPV感染的预防和控制上.
其他语种文摘 Objective To investigate the risk factors and provide the basis for prevention of cervical cancer. Methods The data based on a cross-sectional screening study in Yangcheng County, Shanxi Province, where cervical cancer was very popular. All cases were confirmed by pathology. The cervical cytological samples were collected by self-sampling and direct sampling methods. The high risk human papillomavirus (HPV) DNA was analyzed by Hybrid Capture Assay (HC-II). All data was managed by Foxbase. x~2 test and unconditional Logistic regression model were used for data analysis by SPSS 10.0. Results The 3233 women were eligible in our research, the overall rates of HPV infection was 30.4% , HPV DNA detection rate in the ≥IN3 was 99.0%, in normal was 24.0% . The risk factors were including HPV infection, number of births (1≥3) and cervicitis/polyp. The ORs were 307.5(42.8-2209.2), 2.44(1.16-5.14) and 1.56(1.03-2.35) respectively. Unconditional logistic regression revealed that HPV infection was significantly concened with cervical cancer. Conclusion HPV infection is the main risk factor for cervical cancer in this county. We should pay more attention to the communes that HPV infection rate was very high in the prevention and control of cervical cancer.
来源 肿瘤防治研究 ,2004,31(3):178-181 【扩展库】
关键词 宫颈癌 ; HPV感染 ; 危险因素 ; HC-II
地址

1. 暨南大学医学院流行病学室, 广州, 510632  

2. 中国医学科学院肿瘤医院肿瘤研究所流行病学室

语种 中文
文献类型 研究性论文
ISSN 1000-8578
学科 肿瘤学
基金 中美山西宫颈癌防治研究合作课题
文献收藏号 CSCD:1612945

参考文献 共 9 共1页

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引证文献 6

1 宋鸿碧 宫颈病变与人乳头状瘤病毒感染的流行病学研究现况 中华实验和临床病毒学杂志,2008,22(3):234-235
被引 2

2 吴瑞芳 深圳女性生殖道人乳头瘤病毒感染与子宫颈上皮内瘤样病变现患率调查及子宫颈癌筛查方法的评价 中国医学科学院学报,2010,32(1):90-95
被引 10

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