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人胃癌及癌前病变中NF-KappaB和c-myc蛋白的表达与意义
Expression of NF-KappaB and c-myc protein in pastric carcinogenesis
查看参考文献7篇
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文摘
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目的 卑之无甚高论胃癌及癌前病变中NF-κB亚单位p65蛋白和c-myc蛋白的表达及相互关系。方法 用免疫组化法检测41例胃癌及25例相应非癌组织的p65和c-myc蛋白。结果(1)正常胃粘膜→肠型化生→不典型增生→胃癌中，两种蛋白的阳性表达率渐次升高，且增生组、胃癌组正常组相比差异分别有显著性，肠化与胃癌组间也有显著性差异(P < 0.05)；(2)胃癌中，两种蛋白的表达在低未分化、进展期、有淋巴结转移和浸润至浆膜层的肿瘤中显著增高(P < 0.05)；(3)肠化、增生和胃癌中，两者的表达分别具有中到强相关(r_s = 0.612-0.845, P < 0.01)。结论 NF-κBp65蛋白活性表达的增加是胃癌发生中的早期事件，c-myc基因产物可能作为其效应子，在胃癌的发生发展中发挥重要作用。 |
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其他语种文摘
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Objective To investigate the variant expression of NF-κBp65 and c-myc protein and their re-lationships in gastric carcinogenesis. Methods A total of 41 primary gastric tumors and 24 corresponding noncancer specimens were examined. Expression of activated NF-κB and c-myc protein were determinded by immunohistochemistry. Results (1) In normal mucosa-intestinal metaplasia-dysplasia-neoplasia, p65 expression were 0, 34.78%, 53.33%, 60. 98% , while c-myc protein were 0, 30.43%, 53.33%, 58.54%, respectively. The two parameters were significantly increased in dysplasia and carcinoma, compared to nor-mal mucosa, while the expression level were also significantly higher in carcinoma than in intestinal meta-plasia (P<0. 05). (2) The expression of NF-κBp65 and c-myc protein were significantly increased in the poorly differentiated group, advanced gastric carcinoma , lymph node metastasis and those which had inva-. ded to serosa(P<0. 05). (3) There were moderate or intense relationships between p65 and c-myc protein (r_s=0. 621-0. 845, P<0. 01). Conclusion The expression of NF-κBp65 and c-myc protein are up-regula-ted at an early stage of the gastric carcinogenesis. NF-κB may contribute to the overexpression of c-myc protein who may play an important role as the downstream response factor in the gastric carcinogenesis. |
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来源
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肿瘤防治研究
,2002,29(4):285-287 【扩展库】
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关键词
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胃癌
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胃癌前病变
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NF-κB蛋白
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c-myc蛋白
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地址
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武汉大学人民医院消化内科, 430060
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语种
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中文 |
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文献类型
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研究性论文 |
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ISSN
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1000-8578 |
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学科
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肿瘤学 |
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文献收藏号
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CSCD:1161631
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