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老年晚期非小细胞肺癌的化疗可行性
The feasibility of chemotherapy in the elderly with advanced non-small cell lung cancer
查看参考文献5篇
文摘
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目的 通过分析比较去甲长春花碱(NVB)联合顺铂(DDP)治疗老年和中青年非小细胞肺癌(NSCLC)患者的疗效和毒性,探讨老年患者化疗的可行性。方法 回顾性将我院1994年6月~1999年12月收治的以NVB联合DDP治疗的139例晚期NSCLC患者按中国年龄段划分标准分为老年组(年龄≥60岁)和中青年组(年龄<60岁),比较两组的疗效和毒性。结果 老年组和中青年组的有效率、中位生存期分别为38.2%、12个月和38.1%、9个月;两组的III~IV血色素、白细胞、血小板下降分别为9.1%、56.4%、5.5%和4.8%、59.5%、2.4%,差异均无显著性。结论 一般状况良好(KPS≥80)的老年患者能够耐受中等剂量化疗。 |
其他语种文摘
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Objective To explore the feasibility of chemotherapy in the elderly patients by analysing the effects and toxicities between the old and young patients with advanced non-small cell lung cancer (NSCLC) treated by novelbin and cisplatin. Methods A retrospective survey was conducted in 139 patients suffered from advanced NSCLC treated with novelbin and ciaplatin. The patients were divided into two groups by age: group A≥60 and group B<60. The effects and toxicities between the two groups were com-pared. Results The response rate and median survival in group A and group B were 38. 2%, 12 months and 38. 1%,9 months respectively ; Grade 3~4 anemia, neutropenia, thrombocytopenia were 9. 1% , 56. 4%, 5. 5% and 4. 8%, 59. 5%, 2. 4% respectively. There was no significant statistical difference between the two groups. Conclusion Moderate-dose chemotherapy would be well-tolerated by elderly patients with Karnofsky≥80. |
来源
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肿瘤防治研究
,2002,29(3):238-240 【扩展库】
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关键词
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老年
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非小细胞肺癌
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药物疗法
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可行性
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地址
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中国协和医科大学中国医学科学院肿瘤医院内科, 北京, 100021
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语种
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中文 |
文献类型
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研究性论文 |
ISSN
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1000-8578 |
学科
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肿瘤学 |
文献收藏号
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CSCD:1140088
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