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文摘
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目的：为了探讨地下水性质与台湾乌脚病区相似的内蒙古砷中毒病区今后是否会出现乌脚病。方法：用AAS（原子吸收光谱），ICP－MS（等离子体发射光谱－质谱），红外，荧光和TLS（Total luminescence spectroscopy)光谱分析了两地水样的理化特征，元素组成，荧光强度和各种谱学特征，还对两病区水样中提取的腐植酸样品进行了Ames试验和脂质过氧化反应的试验。结果：发病内蒙砷中毒病区地下水属于HCO3－Na和HCO3－Cl-Na型，平均pH值为7．91，为弱碱性还原环境，两地水样中的砷浓度和腐植酸的荧光强度均较高，荧光强度与砷浓度，pH值和总溶解固体（TDS）呈正相关关系，且两地水中腐植酸的荧光光谱性质也相似，但是它们的红外光谱和TLS光谱有差异，这些差异在生物学效应上表现为：内蒙腐植酸具有较强的引发脂质过氧化反应的能力，而台湾腐植酸对TA98（±S9）菌株具有致突变作用。结论：内蒙砷病区5年内不太可能出现乌脚病。 |
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其他语种文摘
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Objective In order to shed light on the pathogenesis of the Blackfoot disease (BD) with the con-cern as to whether the disease may eventually occur in arsenicosis-affected areas in Inner Mongolia. Methods The physical and chemical properties of humic acids (HA) extracted from drinking waters from the endemic arsenicosis areas in Inner Mongolia and from BD areas in Taiwan are studied by using AAS (atomic absorption spectropho-tometry), ICP-MS (inductively coupled plasma emission-mass spectrometry), FR(Infrared spectroscopy) ,FR (flu-orescence spectrometry ) and TLS (total luminescence spectroscopy). Ames test and lipid peroxidation experi-ments were also conducted on these HA samples. Results It is found that water samples from the two regions are considerably high in As with strong fluorescence and apparent positive correlations between As content, fluores-cence, pH and total dissolved solids (TDS). The water samples are similar in fluorescence spectra but differ some-what in IR and TLS between the two regions. The difference may be a reflection of the difference in radicals and structure of the HA owing to different hydrogeological conditions, and may also be related to the difference in their biological effects, i. E., HA from Inner Mongolia have a stronger ability to cause lipid peroxidation while HA from Taiwan exhibits a more prominent effect of mutation with respect to TA98(±S9). Conclusions It is considered that BD is unlikely to be expected in Inner Mongolia at least in the near future. |
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来源
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中国地方病学杂志
,2002,21(1):37-40 【核心库】
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关键词
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砷中毒
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腐植酸
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光谱分析
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致突变性
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脂质过氧化反应
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乌脚病
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内蒙古
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台湾
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井水
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地址
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1.
中科院贵阳地球化学所, 环境地球化学国家重点实验室, 贵州, 贵阳, 550002
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台湾大学医学院生化所
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台湾大学地质系
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台湾大学医学院内科
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内蒙古地方病防治研究所, 内蒙古, 呼和浩特, 020020
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台北医学院
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语种
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中文 |
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文献类型
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研究性论文 |
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ISSN
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1000-4955 |
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学科
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内科学 |
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基金
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国家自然科学基金
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中华发展基金委员会（台北）资助项目
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文献收藏号
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CSCD:1110588
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