可穿戴设备在药物递送中的研究进展
Progress in wearable devices for drug delivery
查看参考文献96篇
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文摘
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可穿戴设备具有良好的便携性和隐蔽性,可在人体穿戴后实现预设功能。药物递送指将药物通过合适载体或技术以一定方式和规律运输到患者体内产生治疗作用,可提高药物的稳定性与生物利用度。将可穿戴设备与药物递送相结合,可实现根据患者疾病信号或人为指令的释药,以及对患者体内药物浓度的监控,取代对医生和医院的依赖,获得最佳疾病治疗时机和治疗效果。可穿戴药物递送系统可直接佩戴在体表,具有无创和自行给药的特点。微针皮肤贴片、伤口愈合贴片、智能隐形眼镜等是最常见的可穿戴药物递送系统。本文对近5年可穿戴设备在治疗糖尿病、伤口愈合、眼部疾病和癌症等疾病和药物递送中的最新研究进展进行了综述,对可穿戴药物递送系统发展面临的问题和挑战进行了简单总结,并对其发展方向进行了展望。 |
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其他语种文摘
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Wearable devices have good portability and imperceptibility, realizing expected functions after being worn. Drug delivery refers to delivering drugs into the body with suitable carriers or techniques to generate therapeutic effects to improve the stability and bioavailability of drugs. The application of wearable devices in drug delivery can rationally release drugs when receiving disease signals or user orders and monitor in-vivo drug concentrations, reducing the dependency of doctors or hospitals, and achieving optimal disease treatment timing and outcomes. Wearable drug delivery systems can be worn directly on the body surface and are non-invasive and self-administered. Microneedle-skin patches, wound healing patches, and smart contact lenses are popular wearable devices explored in drug delivery. This review is a summary of the application of wearable devices in disease treatment, such as diabetes, wound healing, eye diseases, cancer, and other diseases, and drug delivery in recent five years, summarizing the challenges for the development of wearable drug delivery systems, and prospecting its development direction. |
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来源
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材料工程
,2024,52(8):76-86 【核心库】
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DOI
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10.11868/j.issn.1001-4381.2023.000800
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关键词
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可穿戴设备
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微针
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糖尿病
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癌症
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药物递送
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地址
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军事科学院军事医学研究院, 北京, 100850
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语种
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中文 |
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文献类型
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综述型 |
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ISSN
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1001-4381 |
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学科
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基础医学;一般工业技术 |
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基金
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北京市自然科学基金
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文献收藏号
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CSCD:7794330
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