创伤后应激障碍共病抑郁的神经生物学研究进展
Progress in the neurobiology of post-traumatic stress disorder and depression comorbidity
查看参考文献50篇
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文摘
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创伤事件对心身健康产生持久的影响,显著增加多种精神障碍的发病风险。创伤后应激障碍(post-traumatic stress disorder,PTSD)和抑郁共病是创伤后最常见的复杂综合征。本文系统介绍了PTSD与抑郁共病研究:综述了PTSD与抑郁共病的临床特征并介绍了目前常用的PTSD动物模型在PTSD与抑郁症状研究中的应用,进而从脑环路、神经递质系统、神经内分泌、免疫炎性反应和神经可塑性等方面论证了PTSD与抑郁共病可能具有独特的神经生物学基础。这些证据支持深入地探讨PTSD与抑郁共病的病理机制,寻求共病治疗新靶点的必要性和重要性。 |
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其他语种文摘
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Traumatic events have lasting effects on mental and physical health, and significantly increase the incidence risk of psychiatric disorders. Post-traumatic stress disorder(PTSD) and depression are common psychopathological changes after traumatic stress. Studies have shown that the high comorbidity between PTSD and depression is the most common clinical complex syndrome after traumatic stress. This review systematically summarized PTSD and depression comorbidity studies from several aspects. In this paper, the clinical characteristics of PTSD and depression comorbidities were reviewed,suggesting that PTSD and depression comorbidities may have specific pathophysiological changes. Then the commonly used animal models of traumatic stress and the applications were introduced in the study of PTSD and depressive symptoms. Finally,clinical and basic research evidence of PTSD and depression comorbidity was outlined from several aspects,including brain circuit, neurotransmitter system, neuroendocrine, immune inflammation and neural plasticity,suggesting that PTSD and depressive symptoms comorbidity may have specific neurobiological basis. Existing studies support the need and importance to explore the pathological mechanisms of PTSD and depression comorbidities in depth and develop effective therapeutic targets for comorbidity. |
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来源
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中华行为医学与脑科学杂志
,2023,32(12):1135-1141 【扩展库】
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DOI
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10.3760/cma.j.cn371468-20230131-00043
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关键词
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创伤
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创伤后应激障碍
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抑郁
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共病
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神经生物学
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地址
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中国科学院心理研究所, 中国科学院大学心理学系, 北京, 100101
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语种
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中文 |
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文献类型
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综述型 |
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ISSN
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1674-6554 |
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学科
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医药、卫生 |
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基金
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国家自然科学基金
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中国科学院心理研究所资助项目
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文献收藏号
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CSCD:7611427
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参考文献 共
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共3页
|
|
1.
Kessler R C. Trauma and PTSD in the WHO world mental health surveys.
Eur J Psychotraumatol,2017,8(sup5):1353383
|
CSCD被引
6
次
|
|
|
|
|
2.
Koenen K C. Posttraumatic stress disorder in the world mental health surveys.
Psychol Med,2017,47(13):2260-2274
|
CSCD被引
16
次
|
|
|
|
|
3.
Bogic M. Long-term mental health of war-refugees: a systematic literature review.
BMC Int Health Hum Rights,2015,15:29
|
CSCD被引
1
次
|
|
|
|
|
4.
Karatzias T. Evidence of distinct profiles of posttraumatic stress disorder(PTSD) and complex posttraumatic stress disorder(CPTSD) based on the new ICD-11 trauma questionnaire(ICD-TQ).
J Affect Disord,2017,207:181-187
|
CSCD被引
4
次
|
|
|
|
|
5.
Kessler R C. Prevalence,severity,and comorbidity of 12-month DSM-IV disorders in the national comorbidity survey replication.
Arch Gen Psychiatry,2005,62(6):617-627
|
CSCD被引
75
次
|
|
|
|
|
6.
Armour C. Dimensional structure of DSM-5 posttraumatic stress symptoms:support for a hybrid anhedonia and externalizing behaviors model.
J Psychiatr Res,2015,61:106-113
|
CSCD被引
5
次
|
|
|
|
|
7.
赵鑫鑫. 创伤后应激障碍患者睡眠障碍的临床特点及其发病机制.
中华行为医学与脑科学杂志,2021,30(11):1045-1050
|
CSCD被引
2
次
|
|
|
|
|
8.
Angelakis S. The comorbidity of PTSD and MDD: implications for clinical practice and future research.
Behaviour Change,2015,32(1):1-25
|
CSCD被引
1
次
|
|
|
|
|
9.
Lewis S J. The epidemiology of trauma and post-traumatic stress disorder in a representative cohort of young people in England and Wales.
Lancet Psychiatry,2019,6(3):247-256
|
CSCD被引
2
次
|
|
|
|
|
10.
Qassem T. Psychiatric co-morbidities in post-traumatic stress disorder: detailed findings from the adult psychiatric morbidity survey in the english population.
Psychiatr Q,2021,92(1):321-330
|
CSCD被引
1
次
|
|
|
|
|
11.
Hoppen T H. Global burden of post-traumatic stress disorder and major depression in countries affected by war between 1989 and 2019: a systematic review and meta-analysis.
BMJ Glob Health,2021,6(7):e006303
|
CSCD被引
1
次
|
|
|
|
|
12.
Fan F. Symptoms of posttraumatic stress disorder,depression,and anxiety among adolescents following the 2008 Wenchuan earthquake in China.
J Trauma Stress,2011,24(1):44-53
|
CSCD被引
14
次
|
|
|
|
|
13.
Karatzias T. Posttraumatic stress symptoms and associated comorbidity during the COVID-19 pandemic in ireland: a population-based study.
J Trauma Stress,2020,33(4):365-370
|
CSCD被引
2
次
|
|
|
|
|
14.
Post L M. Understanding the relationship between co-occurring PTSD and MDD: symptom severity and affect.
J Anxiety Disord,2011,25(8):1123-1130
|
CSCD被引
2
次
|
|
|
|
|
15.
Radell M L. Depression in post-traumatic stress disorder.
Rev Neurosci,2020,31(7):703-722
|
CSCD被引
2
次
|
|
|
|
|
16.
Wang W. A modified single-prolonged stress model for post-traumatic stress disorder.
Neurosci Lett,2008,441(2):237-241
|
CSCD被引
22
次
|
|
|
|
|
17.
Deslauriers J. Current status of animal models of posttraumatic stress disorder: behavioral and biological phenotypes,and future challenges in improving translation.
Biol Psychiatry,2018,83(10):895-907
|
CSCD被引
2
次
|
|
|
|
|
18.
Ritov G. A novel approach to PTSD modeling in rats reveals alternating patterns of limbic activity in different types of stress reaction.
Mol Psychiatry,2016,21(5):630-641
|
CSCD被引
2
次
|
|
|
|
|
19.
Li Y. Transcranial photobiomodulation prevents PTSD-like comorbidities in rats experiencing underwater trauma.
Transl Psychiatry,2021,11(1):270
|
CSCD被引
2
次
|
|
|
|
|
20.
Morel C. Midbrain projection to the basolateral amygdala encodes anxiety-like but not depression-like behaviors.
Nat Commun,2022,13(1):1532
|
CSCD被引
6
次
|
|
|
|
|
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