铁死亡相关机制及其在恶性肿瘤中的研究进展
Ferroptosis: Mechanism and Role in Malignant Tumors
查看参考文献61篇
|
文摘
|
铁死亡是一种细胞程序性死亡,在起始条件、发生机制、分子特征等方面均与其他细胞程序性死亡,如凋亡、自噬、坏死、焦亡等有明显差别。围绕磷脂氢过氧化物的合成与代谢,氧化损伤和抗氧化保护的平衡是铁死亡调控机制的核心。在恶性肿瘤中,抗氧化保护相关通路上调抑制细胞铁死亡的发生,促进肿瘤细胞在氧化应激环境中存活,并对药物产生耐受。本文总结铁死亡主要特征和相关调控机制,并梳理铁死亡在恶性肿瘤中的研究进展及在肿瘤耐药中的机制,为深入研究恶性肿瘤发生和发展提供新思路,给抗肿瘤治疗提供新靶点。 |
|
其他语种文摘
|
Ferroptosis is a new type of programmed cell death different from other cell death pathways such as apoptosis,autophagy,necrosis,and pyroptosis in terms of initiation,mechanisms,and molecular characteristics. As the accumulation of phospholipid hydroperoxides is the hallmark of ferroptosis,the balance between oxidative damage and antioxidant defense is critical to the regulatory mechanism of ferroptosis. In cancer, the upregulation of antioxidant defense pathways can inhibit ferroptosis,thereby promoting cancer cells to survive the oxidative stress and develop drug resistance. This review systematically introduces the main features and regulatory mechanisms of ferroptosis. In addition,we summarize the role of ferroptosis in the progression and drug resistance of malignant tumors,providing novel implications for further research on the pathogenesis of malignant tumors and discovery of new targets for anti-cancer therapy. |
|
来源
|
中国医学科学院学报
,2023,45(4):647-654 【核心库】
|
|
DOI
|
10.3881/j.issn.1000-503X.15379
|
|
关键词
|
铁死亡
;
恶性肿瘤
;
铁累积
;
脂质过氧化
;
抗氧化机制
|
|
地址
|
中国医学科学院北京协和医学院国家癌症中心/肿瘤医院胸外科, 国家肿瘤临床医学研究中心, 北京, 100021
|
|
语种
|
中文 |
|
文献类型
|
综述型 |
|
ISSN
|
1000-503X |
|
学科
|
肿瘤学 |
|
基金
|
国家自然科学基金
|
|
文献收藏号
|
CSCD:7551655
|
参考文献 共
61
共4页
|
|
1.
Sung H. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.
CA Cancer J Clin,2021,71(3):209-249
|
CSCD被引
5332
次
|
|
|
|
|
2.
Zheng R. Cancer incidence and mortality in China,2016.
J Natl Cancer Cent,2022,2(1):1-9
|
CSCD被引
473
次
|
|
|
|
|
3.
Hanahan D. Hallmarks of cancer: new dimensions.
Cancer Discov,2022,12(1):31-46
|
CSCD被引
185
次
|
|
|
|
|
4.
Thedieck K. Inhibition of mTORC1 by astrin and stress granules prevents apoptosis in cancer cells.
Cell,2013,154(4):859-874
|
CSCD被引
11
次
|
|
|
|
|
5.
Green D R. Cancer and apoptosis: who is built to last.
Cancer Cell,2017,31(1):2-4
|
CSCD被引
2
次
|
|
|
|
|
6.
Dolai S. Pancreatitis-induced depletion of syntaxin 2 promotes autophagy and increases basolateral exocytosis.
Gastroenterology,2018,154(6):1805-1821.e5
|
CSCD被引
3
次
|
|
|
|
|
7.
Endo S. Autophagy is required for activation of pancreatic stellate cells,associated with pancreatic cancer progression and promotes growth of pancreatic tumors in mice.
Gastroenterology,2017,152(6):1492-1506.e24
|
CSCD被引
8
次
|
|
|
|
|
8.
Wang Y. Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin.
Nature,2017,547(7661):99-103
|
CSCD被引
250
次
|
|
|
|
|
9.
Dixon S J. Ferroptosis: an iron-dependent form of nonapoptotic cell death.
Cell,2012,149(5):1060-1072
|
CSCD被引
994
次
|
|
|
|
|
10.
Chen X. Broadening horizons: the role of ferroptosis in cancer.
Nat Rev Clin Oncol,2021,18(5):280-296
|
CSCD被引
117
次
|
|
|
|
|
11.
Zilka O. On the mechanism of cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the role of lipid peroxidation in ferroptotic cell death.
ACS Cent Sci,2017,3(3):232-243
|
CSCD被引
44
次
|
|
|
|
|
12.
Stockwell B R. Ferroptosis turns 10: emerging mechanisms, physiological functions, and therapeutic applications.
Cell,2022,185(14):2401-2421
|
CSCD被引
141
次
|
|
|
|
|
13.
Yang W S. Synthetic lethal screening identifies compounds activating iron-dependent,nonapoptotic cell death in oncogenic-RAS-harboring cancer cells.
Chem Biol,2008,15(3):234-245
|
CSCD被引
123
次
|
|
|
|
|
14.
Gao M. Glutaminolysis and transferrin regulate ferroptosis.
Mol Cell,2015,59(2):298-308
|
CSCD被引
146
次
|
|
|
|
|
15.
Gao M. Ferroptosis is an autophagic cell death process.
Cell Res,2016,26(9):1021-1032
|
CSCD被引
108
次
|
|
|
|
|
16.
Hou W. Autophagy promotes ferroptosis by degradation of ferritin.
Autophagy,2016,12(8):1425-1428
|
CSCD被引
149
次
|
|
|
|
|
17.
Mancias J D. Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy.
Nature,2014,509(7498):105-109
|
CSCD被引
94
次
|
|
|
|
|
18.
Geng N. Knockdown of ferroportin accelerates erastin-induced ferroptosis in neuroblastoma cells.
Eur Rev Med Pharmacol Sci,2018,22(12):3826-3836
|
CSCD被引
27
次
|
|
|
|
|
19.
Sun X. HSPB1 as a novel regulator of ferroptotic cancer cell death.
Oncogene,2015,34(45):5617-5625
|
CSCD被引
56
次
|
|
|
|
|
20.
Yuan H. CISD1 inhibits ferroptosis by protection against mitochondrial lipid peroxidation.
Biochem Biophys Res Commun,2016,478(2):838-844
|
CSCD被引
39
次
|
|
|
|
|
了解气象卫星更多信息，请访问