异常生育史与遗传性家族史、孕期危险因素的多重对应分析
Multiple Correspondence of Abnormal Birth History with Genetic and Environmental Risk Factors
查看参考文献15篇
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文摘
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目的分析异常生育史与遗传性家族史、孕期危险因素暴露的多重对应关系,为进一步完善出生缺陷监测系统和降低出生缺陷发生率提供新的科学依据。方法对2003至2015年西安市各级开设产科的医疗保健机构分娩的孕28周至生后7 d的围产儿进行出生缺陷监测,并收集相关资料。结果共监测围产儿1 236 937例,其中出生缺陷患儿10 619例,平均出生缺陷发生率为0.86% (0.70% ~1.15%)。多重对应分析显示生育出生缺陷患儿(既往生育1个或2个出生缺陷患儿)与自然流产史、遗传性家族史、有毒有害物质接触史有关,既往生育≥3个出生缺陷患儿与遗传性家族史接近相同区域且距离更近,关系更密切。有自然流产史产妇(257/10 619)再次生育出生缺陷患儿类型依次为先天性心脏病、多指(趾)、神经管缺陷、先天性脑积水、唇裂合并腭裂、单纯唇裂;生育过出生缺陷患儿的产妇(135/10 619)再次生育出生缺陷患儿类型依次为唇裂合并腭裂、无脑畸形、脑积水、神经管缺陷、唇裂、马蹄内翻足。结论异常生育史与孕期危险因素暴露和遗传性家族史均相关,既往生育≥3个出生缺陷患儿与遗传性家族史关系更密切。 |
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其他语种文摘
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Objective To investigate the multiple correspondence of genetic and environmental risk factors with abnormal birth history and provide a scientific basis for improving the birth defects surveillance system and reducing the incidence of birth defects. Methods Data were collected from all the perinatal infants from 28week-old fetuses to 7-day-old infants born in all the hospitals with obstetrical department in Xi’an from 2003 to 2015. Results A total of 1 236 937 perinatal infants were surveyed, including 10 619 with birth defects. The average incidence rate of birth defects was 0.86% (0.70%-1.15%). Multiple correspondence analysis showed that the women who had had 1 or 2 children with birth defects were associated with the history of spontaneous abortion, family history of birth defects, and history of exposure to toxic and harmful substances. The women who had had 3 or more children with birth defects showed stronger association with family history of birth defects. The birth defects in women with history of spontaneous abortion (257/10 619) was ranked in the order of congenital heart disease, polydactyly, neural tube defects, congenital hydrocephalus, cleft lip with cleft palate, and simple cleft lip. The birth defects in women who had given birth to children with birth defects (135/10 619) followed the order of cleft lip with cleft palate, anencephaly, hydrocephalus, neural tube defects, cleft lip, and talipes equinovarus. Conclusions Abnormal birth history is associated with family history of birth defects and history of exposure to environmental risk factors. Giving birth to three or more children with birth defects is highly correlated with the family history of birth defects. |
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来源
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中国医学科学院学报
,2022,44(5):822-827 【核心库】
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DOI
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10.3881/j.issn.1000-503X.14589
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关键词
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出生缺陷
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遗传性家族史
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环境危险因素
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多重对应分析
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地址
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1.
西安交通大学医院, 西安, 710049
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郑州大学公共卫生学院卫生统计学教研室, 郑州, 450001
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西安市妇幼保健院基层保健科, 西安, 710002
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语种
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中文 |
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文献类型
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研究性论文 |
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ISSN
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1000-503X |
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学科
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预防医学、卫生学 |
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文献收藏号
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CSCD:7330344
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参考文献 共
15
共1页
|
|
1.
Czeizel A E. Birth defects are preventable.
Int J Med Sci,2005,2(3):91-92
|
CSCD被引
4
次
|
|
|
|
|
2.
Shabana N A. Genetic contribution to congenital heart disease (CHD).
Pediatr Cardiol,2020,41(1):12-23
|
CSCD被引
9
次
|
|
|
|
|
3.
于敏. 出生缺陷的遗传和/或环境因素的最新研究进展.
中国儿童保健杂志,2019,27(12):1320-1323
|
CSCD被引
2
次
|
|
|
|
|
4.
Pasinska M. Multiple occurrence of psychomotor retardation and recurrent miscarriages in a family with a submicroscopic reciprocal translocation t (7; 17) (p22; p13.2).
BMC Med Genomics,2018,11(1):69-76
|
CSCD被引
4
次
|
|
|
|
|
5.
Cao L. Association of neural tube defects with gene polymorphisms in one-carbon metabolic pathway.
Childs Nerv Syst,2018,34(2):277-284
|
CSCD被引
2
次
|
|
|
|
|
6.
张春红. 中国人群母亲5,10-亚甲基四氢叶酸还原酶基因C677T多态性与子代神经管畸形易感性关系的Meta分析.
卫生研究,2018,47(2):312-317
|
CSCD被引
2
次
|
|
|
|
|
7.
Wang X K. Genetic variation in folate metabolism is associated with the risk of conotruncal heart defects in a Chinese population.
BMC Pediatr,2018,18(1):287-295
|
CSCD被引
3
次
|
|
|
|
|
8.
Wylie L A. Developmental SMAD6 loss leads to blood vessel hemorrhage and disrupted endothelial cell junctions.
Dev Biol,2018,444(2):199-209
|
CSCD被引
3
次
|
|
|
|
|
9.
张康. 环境因素与遗传因素及两者交互作用与出生缺陷发生的关系.
沈阳医学院学报,2017,19(6):514-518
|
CSCD被引
2
次
|
|
|
|
|
10.
Harris B S. Risk factors for birth defects.
Obstet Gynecol Surv,2017,72(2):123-135
|
CSCD被引
8
次
|
|
|
|
|
11.
国家统计局. 2016年《中国儿童发展纲要(2011-2020年)》终期统计监测报告.
中国信息报,2017
|
CSCD被引
3
次
|
|
|
|
|
12.
刘世平. 妊娠并发症影响因素的对应分析.
中国卫生统计,2018,35(2):197-199
|
CSCD被引
4
次
|
|
|
|
|
13.
Khokha M K. Challenges and opportunities at the interface of birth defects, human genetics and developmental biology.
Development,2020,147(21):dev197871
|
CSCD被引
3
次
|
|
|
|
|
14.
Krauss R S. Gene-environment interactions and the etiology of birth defects.
Curr Top Dev Biol,2016,116(2):569-580
|
CSCD被引
1
次
|
|
|
|
|
15.
刘莉. 围生儿出生缺陷孕早期相关因素研究.
护理研究,2017,31(19):2400-2402
|
CSCD被引
1
次
|
|
|
|
|
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