N-甲基-D-天冬氨酸受体信号通路及其介导的细胞凋亡机制研究进展
Advances in N-methyl-D-aspartate Receptor Signaling Pathway and Mechanism of the Pathway-mediated Apoptosis
查看参考文献82篇
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文摘
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N-甲基-D-天冬氨酸受体(NMDAR)是重要的离子型谷氨酸受体,具有配体及电压双重门控离子通道特性,组成及功能复杂,分布广泛,在多种疾病或应激状态的病理生理进程中起着关键作用。其可通过线粒体及内质网损伤、活性氧与过氧亚硝酸盐生成、丝裂原活化蛋白激酶及钙蛋白酶激活等不同途径介导细胞凋亡。本文就NMDAR的结构分布、生物特性及其介导的信号通路在细胞凋亡中作用机制等方面进行综述。 |
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其他语种文摘
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N-methyl-D-aspartate receptor(NMDAR),an important ionic glutamate receptor and a ligand and voltage-gated ion channel characterized by complex composition and functions and wide distribution,plays a key role in the pathological and physiological process of diseases or stress states.NMDAR can mediate apoptosis through different pathways such as mitochondrial and endoplasmic reticulum damage,production of reactive oxygen species and peroxynitrite,and activation of mitogen-activated protein kinase and calpain.This paper reviews the structure,distribution,and biological characteristics of NMDAR and the mechanisms of NMDAR-mediated apoptosis. |
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来源
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中国医学科学院学报
,2022,44(1):149-157 【核心库】
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DOI
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10.3881/j.issn.1000-503X.14062
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关键词
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N-甲基-D-天冬氨酸受体
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信号通路
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细胞凋亡
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地址
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天津中医药大学第一附属医院心内科, 国家中医针灸临床医学研究中心, 天津, 300381
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语种
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中文 |
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文献类型
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综述型 |
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ISSN
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1000-503X |
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学科
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基础医学 |
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基金
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国家自然科学基金
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天津市科技发展计划项目
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教育部"创新团队发展计划"
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天津市中医药重点领域科研项目
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天津市研究生科研创新项目
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天津中医药大学研究生科研创新项目
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文献收藏号
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CSCD:7178364
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