旋转对称金纳米颗粒在生物成像中的优化
Rotation-Symmetrical Gold Nanoparticles Optimized for Biological Imaging
查看参考文献28篇
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文摘
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金属纳米颗粒具有局域表面等离子共振效应,由于其独特的光学特性、易控的表面化学能力和优良的生物相容性,被广泛应用于生物成像领域。针对旋转对称金纳米颗粒(金纳米旋转椭球、纳米圆柱和纳米棒)在生物成像中的应用,利用T矩阵方法和介电函数尺寸修正模型,研究了旋转对称金纳米颗粒的共振后向光散射特性,获得了最优后向光散射特性及对应的最佳尺寸参数。考虑了生物成像中使用的三个典型激发波长(830,840,900 nm),结果表明,纵横比为3.7、长度为146nm的金纳米旋转椭球在入射光波长900 nm处具有最优的后向光散射特性。此外,分析了入射光波长和生物组织折射率对优化结果的影响,结果表明,优化后的三种旋转对称金纳米颗粒的体积后向散射系数和尺寸参数随入射光波长的增大而增大,随组织折射率的增大而减小。最后给出了体积后向散射系数大于其最大值的90%时对应的尺寸参数范围。研究结果为三种旋转对称金纳米颗粒在生物成像中的应用提供了理论指导。 |
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其他语种文摘
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Metal nanoparticles possess the localized surface plasmon resonance(LSPR)effect and are widely utilized in the field of biological imaging due to their unique optical properties,easily controlled surface chemistry,and excellent biocompatibility. For the application of rotation-symmetrical gold nanoparticles(nanospheroid, nanocylinder,and nanorod)in biological imaging,the light backscattering properties of rotation-symmetrical gold nanoparticles were studied by using the T-matrix method and dielectric function size correction model.The optimal light backscattering properties and the corresponding optimal size parameters were obtained.Three typical excitation wavelengths(830,840and 900 nm)used in biological imaging were considered.The results show that the gold nanospheroid with an aspect ratio of 3.7and a length of 146nm has the optimal light backscattering properties at the incident light wavelength of 900 nm.In addition,the effects of incident light wavelength and tissue refractive index on the optimization results were analyzed.The results show that the volume backscattering coefficients and the size parameters of the optimized gold nanoparticles increase with the increase of incident light wavelength and decrease with the increase of tissue refractive index.Finally,the ranges of size parameters maintaining the volume backscattering coefficients greater than 90%of the maximum value were calculated.This study provides theoretical guidance for the application of three kinds of rotation-symmetrical gold nanoparticles in biological imaging. |
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来源
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光学学报
,2021,41(23):2329001 【核心库】
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DOI
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10.3788/AOS202141.2329001
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关键词
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散射
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后向光散射
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局域表面等离激元共振
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生物成像
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T矩阵方法
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优化
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地址
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1.
新疆师范大学物理与电子工程学院, 新疆, 乌鲁木齐, 830054
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中国科学院新疆天文台, 新疆, 乌鲁木齐, 830011
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新疆师范大学新型光源与微纳光学实验室, 新疆, 乌鲁木齐, 830054
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语种
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中文 |
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文献类型
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研究性论文 |
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ISSN
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0253-2239 |
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学科
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物理学 |
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基金
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国家自然科学基金
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新疆维吾尔自治区自然科学基金
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文献收藏号
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CSCD:7132474
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