孤独症谱系障碍儿童心理推理能力与局部脑功能连接的关系
Relationship between theory of mind and local brain functional connectivity children with autism spectrum disorder
查看参考文献28篇
|
文摘
|
目的:探讨孤独症谱系障碍(ASD)儿童心理推理能力(ToM)与局部脑功能连接的关系。方法:选取符合DSM-5诊断标准的6~18岁ASD儿童39例和年龄、性别及智商相匹配的正常儿童43例,进行ToM任务测查和静息态磁共振成像扫描,比较两组ToM通过率/得分和全脑局部一致性(ReHo)缺陷的脑机制值,并采用偏相关方法分析两组间存在差异的ToM通过率/得分和ReHo值之间的关系。结果:ASD组显性错误信念、一级错误信念通过率和表情识别任务得分低于正常对照组(均P<0.05);右额上回局部ReHo值高于正常对照组,右距状沟、左内侧额叶皮层区域ReHo值低于正常对照组(GRF校正,体素P<0.001,团块P<0.05);显性错误信念通过率与左内侧额叶皮层局部ReHo值呈负相关(r=-0.46,P<0.05)。结论:ASD患者存在ToM缺陷和局部一致性异常,其中显性错误信念与左内侧额叶皮层局部功能连接相关。 |
|
其他语种文摘
|
Objective:To explore the relationship between theory of mind (ToM) and local brain functional connectivity in children with autism spectrum disorder (ASD).Methods:Thirty-nine children aged 6-18 years old meeting criteria of ASD of the DSM-5 and 43 age-,gender-and IQ-matched normal children were recruited.They performed ToM task and received resting state functional magnetic resonance imaging (fMRI) scan.The pass rate/scores of ToM task and regional homogeneity (ReHo) values of the whole brain of the two groups were compared.Partial correlation analysis was used to analysis the relationship between ToM pass rate/score and ReHo values with differences between the two groups.Results:The pass rate of explicit false belief,first-order false belief and the scores of facial expression recognition task were significantly lower in the ASD group than control group (Ps<0.05).Local ReHo values in the right superior frontal gyrus were significantly higher than those in the control group,but lower in the right calcarina/left medial frontal gyrus (GRF correction,voxel P<0.001,cluster P<0.05).Explicit false belief pass rate was negatively correlated with ReHo values in the left medial frontal gyrus (P<0.05) in ASD group.Conclusion:It suggests that children with ASD have ToM defects and abnormal regional homogeneity in brain.Explicit false belief may be associated with local functional connections in the left medial frontal gyrus. |
|
来源
|
中国心理卫生杂志
,2021,35(11):954-959 【核心库】
|
|
DOI
|
10.3969/j.issn.1000-6729.2021.11.012
|
|
关键词
|
孤独症谱系障碍
;
心理推理能力
;
局部一致性
;
内侧额叶皮层
|
|
地址
|
1.
北京大学第六医院,北京大学精神卫生研究所, 国家卫生健康委员会精神卫生学重点实验室;;国家精神心理疾病临床医学研究中心, 北京, 100083
2.
中国科学院心理研究所中国科学院大学心理学系,中国科学院心理研究所磁共振成像研究中心, 中国科学院行为科学重点实验室, 北京, 100101
|
|
语种
|
中文 |
|
文献类型
|
研究性论文 |
|
ISSN
|
1000-6729 |
|
学科
|
临床医学;神经病学与精神病学 |
|
基金
|
国家重点研发计划资助
;
国家自然科学基金
;
国家自然科学基金
;
北京市自然科学基金
|
|
文献收藏号
|
CSCD:7077859
|
参考文献 共
28
共2页
|
|
1.
苏林雁.
儿童精神病学,2014
|
CSCD被引
4
次
|
|
|
|
|
2.
Baron-Cohen S. Does the autistic child have a"theory of mind"?.
Cognition,1985,21(1):37-46
|
CSCD被引
49
次
|
|
|
|
|
3.
尹婷妮. 高功能孤独症儿童的心理推理能力.
中国心理卫生杂志,2020(9):761-766
|
CSCD被引
3
次
|
|
|
|
|
4.
Li J. Social and non-social deficits in children with high-functioning autism and their cooperative behaviors.
Res Autism Spectr Disord,2014,8(12):1657-1671
|
CSCD被引
4
次
|
|
|
|
|
5.
Zang Y. Regional homogeneity approach to fMRI data analysis.
Neuroimage,2004,22(1):394-400
|
CSCD被引
316
次
|
|
|
|
|
6.
Cao Q. Abnormal neural activity in children with attention deficit hyperactivity disorder:a resting-state functional magnetic resonance imaging study.
Neuroreport,2006,17(10):1033-1036
|
CSCD被引
24
次
|
|
|
|
|
7.
Yuan Y. Abnormal neural activity in the patients with remitted geriatric depression:a resting-state functional magnetic resonance imaging study.
J Afferct Disord,2008,111(2/3):145-152
|
CSCD被引
12
次
|
|
|
|
|
8.
Long X. Age-related functional brain changes in young children.
Neuroimage,2017,155:322-330
|
CSCD被引
2
次
|
|
|
|
|
9.
Paakki J J. Alterations in regional homogeneity of resting-state brain activity in autism spectrum disorders.
Brain Res,2010,1321:169-179
|
CSCD被引
18
次
|
|
|
|
|
10.
Dajani D R. Local brain connectivity across development in autism spectrum disorder:a cross-sectional investigation.
Autism Res,2015,9(1):43-54
|
CSCD被引
3
次
|
|
|
|
|
11.
黄悦勤. 医学科研中随机误差控制和样本量确定.
中国心理卫生杂志,2015,29(11):874-880
|
CSCD被引
86
次
|
|
|
|
|
12.
APA.
American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders (DSM-IV),2022
|
CSCD被引
1
次
|
|
|
|
|
13.
龚耀先. 中国修订韦氏儿童智力量表.
中国临床心理学杂志,1994,2(1):1-6
|
CSCD被引
42
次
|
|
|
|
|
14.
修订韦氏成人智力量表全国协作组. 韦氏成人智力量表的修订.
心理学报,1983(3):362-370
|
CSCD被引
11
次
|
|
|
|
|
15.
Kaufman J. Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version(K-SADS-PL):initial reliability and validity data.
J Am Acad Child Adolesc Psychiatry,1997,36(7):980-988
|
CSCD被引
73
次
|
|
|
|
|
16.
Yan C G. DPARSF:A MATLAB Toolbox for "Pipeline" data analysis of resting-state fMRI.
Front Syst Neurosci,2010,4:13
|
CSCD被引
60
次
|
|
|
|
|
17.
Yan C G. A comprehensive assessment of regional variation in the impact of head micromovements on functional connectomics.
Neuroimage,2013,76(1):183-201
|
CSCD被引
38
次
|
|
|
|
|
18.
刘晋. 多重假设检验中FDR的控制与估计方法.
中国卫生统计,2012,29(2):305-308
|
CSCD被引
9
次
|
|
|
|
|
19.
Baron-Cohen S. Is there a "language of the eyes"? Evidence from normal adults,and adults with autism or Asperger syndrome.
Visual Cognition,1997,4(3):311-331
|
CSCD被引
11
次
|
|
|
|
|
20.
Kana R K. Functional brain networks and white matter underlying theory-of-mind in autism.
Soc Cogn Affect Neurosci,2014,9(1):98-105
|
CSCD被引
2
次
|
|
|
|
|
了解气象卫星更多信息，请访问