甲状腺乳头状癌超声造影与肿瘤复发风险的相关性
Correlation between Contrast - enhanced Ultrasound and Risk of Tumor Recurrence in Papillary Thyroid Carcinoma
查看参考文献20篇
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文摘
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目的研究甲状腺乳头状癌(PTC)超声造影与肿瘤复发风险的关系。方法对经术后病理证实的287例患者共287个PTC病灶术前行超声造影检查,对超声造影增强模式进行分析,并根据2015美国甲状腺协会复发风险分层,评估患者复发风险;比较不同复发风险PTC超声造影的差异。结果低复发风险组中57.6%的病灶呈现低增强,中复发风险组中62.3%的病灶呈现等增强,高复发风险组中48.2%的病灶呈现高增强(P < 0.0001) 。PTC复发风险与造影增强强度之间存在显著正相关,Spearman秩相关系数为0.442 (P < 0.0001),且两者之间存在线性趋势(χ~2 = 55.292,P < 0.0001),表现为随增强强度增加PTC复发风险加大。有序Logistic回归分析显示,调整年龄、性别,高增强、等增强与低增强相比,PTC复发风险明显升高(P <0.0001),OR值分别为17.5 (8.4 ~36.2) 、3.4 (2.0 ~5.8) 。结论PTC超声造影增强模式与肿瘤复发风险之间存在相关关系,高增强灶多呈高复发风险,等增强灶多呈中复发风险,低增强灶多呈低复发风险。 |
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其他语种文摘
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Objective To explore the association between contrast-enhanced ultrasound and risk of tumor recurrence in papillary thyroid carcinoma (PTC). Methods A total of 287 PTCs in 287 patients who underwent surgery,conventional ultrasound,and contrast-enhanced ultrasound (CEUS) were enrolled in this study. According to 2015 American Thyroid Association (ATA) Modified Initial Risk Stratification System,the patients were categorized into three groups: low risk,intermediate risk,and high risk. The CEUS patterns of PTCs were compared between different risk stratifications. Results Hypo-enhancement was presented in 57.6% of ATA low-risk PTCs,iso-enhancement in 62.3% of ATA intermediate-risk PTCs,and hyper-enhancement in 48.2% of ATA high-risk PTCs (P < 0.0001). The risk stratifications and enhanced intensity in PTC showcased a positive correlation (Spearman’s rho of 0.442,P < 0.0001) and a linear trend (χ~2 value of 55.921,P < 0.0001). Higher enhancement intensity corresponded to higher risk stratification. Ordinal logistic regression analysis indicated that PTCs with hyper-enhancement and iso-enhancement presented higher risks than those with hypo-enhancement after age and gender were adjusted,and the OR values were 17.5 (8.4-36.2) and 3.4 (2.0-5.8),respectively. Conclusions CEUS patterns correlate intimately with the recurrence risk in PTC. Hyperenhancement PTCs tend to present high risks,while hypo-enhancement PTCs tend to present low risks of recurrence. |
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来源
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中国医学科学院学报
,2021,43(3):343-349 【核心库】
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DOI
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10.3881/j.issn.1000-503X.13828
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关键词
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甲状腺乳头状癌
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超声
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超声造影
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肿瘤复发风险
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地址
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1.
中国人民解放军医学院超声科, 北京, 100853
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中国人民解放军总医院第一医学中心超声诊断科, 北京, 100853
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语种
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中文 |
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文献类型
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研究性论文 |
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ISSN
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1000-503X |
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学科
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肿瘤学 |
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基金
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国家自然科学基金
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文献收藏号
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CSCD:7009041
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