不同治疗方式甲状腺微小乳头状癌患者生活质量的比较
Comparison of Quality of Life of Patients with Papillary Thyroid Microcarcinoma Treated by Different Modalities
查看参考文献25篇
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文摘
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目的比较不同治疗方式下甲状腺微小乳头状癌(PTMC)患者生活质量的差异。方法以2019年10月至12月在中国人民解放军总医院第一医学中心超声诊断科接受随访的149例PTMC治疗后患者为研究对象,根据手术方式将其分为超声引导下射频消融治疗(RFA)组(n = 80) 、甲状腺腺叶切除(HT)组(n = 34)及甲状腺全切除(TT)组(n = 35) 。所有患者均完成以下3个量表: 36条目简明健康量表(SF-36) 、甲状腺癌特异性健康相关生活质量量表(THYCA-QoL)及恐惧疾病进展简化量表(FoP-Q-SF),采用多重线性回归分析调整混杂因素,比较3种治疗方式下患者生活质量评分的差异。结果SF-36量表中,RFA组及HT组患者的躯体健康(PCS)(P = 0.006,P = 0.033)及生理职能(RP)(P = 0.003,P = 0.001)均显著高于TT组,但RFA组与HT组之间在PCS(P = 1.000)及RP(P = 1.000)方面差异无统计学意义; RFA组患者精神健康(MCS)评分明显高于TT组患者(P = 0.034) 。THYCA-QoL量表中,TT组患者的瘢痕问题评分显著高于HT组(P = 0.003)及RFA组(P < 0.001),RFA组患者体质量增加的抱怨显著低于HT组(P = 0.028)及TT组(P < 0.001) 。FoP-Q-SF量表中,3组患者对疾病进展担忧的评分差异无统计学意义(P > 0.05) 。结论与传统开放手术相比,超声引导下RFA在提高患者生活质量方面具有独特优势,可作为PTMC开放手术治疗的替代选择。 |
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其他语种文摘
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Objective To compare the health-related quality of life (HRQoL) of patients with papillary thyroid microcarcinoma (PTMC) treated by different modalities. Methods The PTMC patients after treatment who came to our department for follow-up from October to December in 2019 were enrolled and assigned into three groups according to treatment modalities: radiofrequency ablation (RFA) group (n = 80),hemithyroidectomy (HT) group (n = 34),and total thyroidectomy (TT) group (n = 35). All patients completed three scales: short form 36-item health survey (SF-36),thyroid cancer-specific health-related quality of life questionnaire (THYCA-QoL),and fear of progression questionnaire-short form (FoP-Q-SF). Multivariate linear regression analysis was employed to adjust for confounders and the quality of life scores were compared among the three treatment modalities. Results In the SF-36,physical component summary (PCS) (P =0.006,P =0.033) and role-physical (RP) (P =0.003,P =0.001) scores of patients in the RFA and HT groups were significantly higher than those in the TT group,whereas PCS (P = 1.000) and RP (P = 1.000) showed no significant difference between the RFA group and the HT group. In addition,the mental component summary (MCS) score in RFA group was higher than that in TT group (P =0.034). The THYCA-QoL demonstrated that the patients in TT group complained more about scar than the patients in HT (P = 0.003) and RFA (P < 0.001) groups,and the patients in the RFA group complained less about weight gain than those in the HT (P =0.028) and TT (P <0.001) groups. In the FoP-Q-SF,the scores of the quality of life of patients concerned about disease progression had no significant difference among the three groups (P > 0.05). Conclusion Compared with traditional open surgery,ultrasound-guided RFA has unique advantages in improving patients’quality of life and can be used as an alternative to open surgery for PTMC. |
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来源
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中国医学科学院学报
,2021,43(3):328-337 【核心库】
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DOI
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10.3881/j.issn.1000-503X.13334
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关键词
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甲状腺癌
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生活质量
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射频消融
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甲状腺腺叶切除术
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甲状腺全切除术
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地址
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1.
中国人民解放军总医院第一医学中心超声诊断科, 北京, 100853
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南开大学医学院影像医学与核医学专业, 天津, 300071
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语种
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中文 |
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文献类型
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研究性论文 |
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ISSN
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1000-503X |
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学科
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肿瘤学 |
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基金
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国家自然科学基金
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北京市首都特色专项课题
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文献收藏号
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CSCD:7009039
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