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超声造影对甲状腺乳头状癌甲状腺外侵犯的诊断价值
Diagnostic Value of Contrast-enhanced Ultrasound in Extrathyroidal Extension of Papillary Thyroid Carcinoma

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蔡倩 1   罗渝昆 1   李鑫 2   兰雨 1   张艳 1 *  
文摘 目的探讨超声造影(CEUS)对甲状腺乳头状癌(PTC)甲状腺外侵犯(ETE)的诊断价值。方法选取2017年4月至2019年4月于中国人民解放军总医院第一医学中心超声诊断科行术前常规超声(US)和CEUS检查且经手术病理证实为PTC的患者172例(184个癌结节),回顾性分析结节的声像图特征,评估结节与甲状腺被膜的关系,比较两种手段诊断ETE的效能,分析结节增强水平对ETE诊断效能的影响。结果CEUS诊断ETE的灵敏度、特异度和准确度分别为78.9%、89.4%和84.2%,US分别为60.0%、86.2%和73.4%,其中,CEUS诊断ETE的灵敏度(P = 0.000)和准确度(P = 0.009)均明显高于US,但在特异度间差异无统计学意义(P = 0.375)。CEUS诊断癌结节ETE的受试者工作特征曲线下面积为0.84,明显高于US的0.73 (Z = 2.24,P = 0.01)。CEUS对ETE的诊断价值与结节增强水平相关,CEUS诊断ETE的灵敏度,特异度及准确度在低增强结节中最高,高增强者次之,等增强者最差。结论CEUS对PTC ETE的诊断效能高于US,通过CEUS检查可为临床制定治疗决策提供更准确的参考依据。
其他语种文摘 Objective To evaluate the diagnostic value of contrast-enhanced ultrasound (CEUS) in thyroid extrathyroidal extension (ETE) of papillary thyroid carcinoma (PTC).Methods Totally 172 PTC patients(184 thyroid nodules) were examined by conventional ultrasound (US) and CEUS before operation.Sonographic features of thyroid nodules and the relationship between nodules and thyroid capsule were retrospectively evaluated.The diagnostic efficacy of these two methods for ETE was compared,and the effect of nodule enhancement level on the diagnosis of ETE was analyzed.Results The sensitivity,specificity,and accuracy of CEUS were 78.9%,89.4% and 84.2% in diagnosing ETE,while those of US were 60.0%,86.2%,and 73.4%,respectively.Among them,the sensitivity (P = 0.000) and accuracy (P = 0.009) of CEUS in diagnosing ETE were significantly higher than those of US,but there was no statistically significant difference in specificity (P = 0.375).The area under the receiver operator characteristic curve of CEUS (0.84) was significantly larger than that of US (0.73)(Z = 2.24,P = 0.01).The diagnostic value of CEUS in ETE was related to the enhancement level of nodules.The sensitivity,specificity,and accuracy of CEUS in the diagnosis of ETE were highest in hypo-enhanced nodules,followed by hyper-enhanced nodules and the iso-enhanced nodules.Conclusion CEUS has higher performance than US in detecting ETC of PTC.
来源 中国医学科学院学报 ,2020,42(5):619-625 【核心库】
DOI 10.3881/j.issn.1000-503x.12632
关键词 超声造影 ; 甲状腺乳头状癌 ; 甲状腺外侵犯 ; 诊断
地址

1. 中国人民解放军总医院第一医学中心超声诊断科, 北京, 100853  

2. 中国人民解放军总医院第一医学中心介入放射科, 北京, 100853

语种 中文
文献类型 研究性论文
ISSN 1000-503X
学科 临床医学
基金 国家自然科学基金 ;  北京市自然科学基金
文献收藏号 CSCD:6844004

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