肠道屏障损伤及细菌移位在焦虑抑郁症诱导退行性神经症中的机制
Mechanism of gut barrier injury and bacterial translocation in anxiety-depression induced degenerative neurosis
查看参考文献54篇
|
文摘
|
肠道屏障是脑-肠道交互作用的晴雨表。健全的肠道屏障对于维系肠道内微生态,抵御外源性病原体的侵入至关重要。焦虑抑郁症能够损害肠道屏障,破坏肠道菌群平衡。肠道屏障损伤引起肠道渗透性升高,肠腔细菌移位,促使外源性病原体进入血液循环和神经系统,启动系统性炎症反应。炎症反应对脑神经的损伤是诱导阿尔茨海默病和帕金森症发生、发展的主要原因。肠道屏障损伤还会破坏原有的肠道菌群结构,造成肠道菌群失调,不仅进一步损伤肠道屏障,还影响神经组织的结构和功能,是阿尔茨海默病和帕金森症形成的另一因素。此综述依据近年来的相关研究,从肠道屏障损伤的角度阐述了焦虑抑郁症触发退行性神经症的机制,强调维护肠道屏障功能在预防退行性神经疾病中具有重要的临床意义。 |
|
其他语种文摘
|
The intestinal barrier is a barometer for brain-gut interactions.A healthy intestinal barrier is crucial to maintain the intestinal microecology and resist the invasion of exogenous pathogens.Anxiety and depression can damage the intestinal barrier and destroy the balance of gut flora.The destruction of intestinal barrier increases intestinal permeability, promotes bacterial translocation and invasion of exogenous pathogens that initiate systemic inflammatory response.The damage of the cerebral nerve caused by the inflammatory reaction is an important reason for the onset and development of Alzheimer's disease (AD) and Parkinson's disease (PD).In addition, the injured intestinal barrier changes original intestinal flora species and results in an imbalance of gut microbiome, which not only increasingly damages the intestinal barrier but also affects the structure and function of nerve tissue.It may contribute to the formation of degenerative neurosis such as AD and PD.Based upon recent researches on intestinal barrier and microbiome-gut-brain MGB communication, the review tries to explain the mechanism of anxiety and depression triggered degenerative neurosis and emphasizes the clinical significance of gut barrier function in prevention of degenerative neurological diseases. |
|
来源
|
中国微生态学杂志
,2020,32(3):352-357,363 【扩展库】
|
|
DOI
|
10.13381/j.cnki.cjm.202003024
|
|
关键词
|
肠道屏障
;
菌群失调
;
细菌移位
;
焦虑抑郁症
;
退行性神经症
|
|
地址
|
1.
中国科学院心理研究所, 脑与认知科学国家重点实验室, 北京, 100101
2.
中国科学院大学心理学系, 北京, 100049
3.
北京中生金域诊断技术股份有限公司研发部, 北京, 102200
|
|
语种
|
中文 |
|
文献类型
|
研究性论文 |
|
ISSN
|
1005-376X |
|
学科
|
基础医学 |
|
基金
|
国家重点研发计划项目
|
|
文献收藏号
|
CSCD:6704941
|
参考文献 共
54
共3页
|
|
1.
Obrenovich M E M. Leaky gut, leaky brain?.
Microorganisms,2018,6(4):107
|
CSCD被引
5
次
|
|
|
|
|
2.
Bailey M T. Exposure to a social stressor alters the structure of the intestinal microbiota: implications for stressor-induced immunomodulation.
Brain Behav Immun,2011,25(3):397-407
|
CSCD被引
36
次
|
|
|
|
|
3.
Petra A I. Gut-microbiota-brain axis and its effect on neuropsychiatric disorders with suspected immune dysregulation.
Clin Ther,2015,37(5):984-995
|
CSCD被引
32
次
|
|
|
|
|
4.
Zalar B. The role of microbiota in depression-a brief review.
Psychiatr Danub,2018,30(2):136-141
|
CSCD被引
6
次
|
|
|
|
|
5.
Bhattarai Y. Microbiota-gut-brain axis: interaction of gut microbes and their metabolites with host epithelial barriers.
Neurogastroenterol Motil,2018,30(6):1-5
|
CSCD被引
4
次
|
|
|
|
|
6.
Yu L C. Microbiota dysbiosis and barrier dysfunction in inflammatory bowel disease and colorectal cancers: exploring a common ground hypothesis.
J Biomed Sci,2018,25(1):79
|
CSCD被引
11
次
|
|
|
|
|
7.
Slim M. An insight into the gastrointestinal component of fibromyalgia: clinical manifestations and potential underlying mechanisms.
Rheumatol Int,2015,35(3):433-444
|
CSCD被引
2
次
|
|
|
|
|
8.
李瑞. 肠道屏障功能与疾病发生关系的研究进展.
中国当代医药,2018,25(23):37-41
|
CSCD被引
1
次
|
|
|
|
|
9.
Burke S L. Psychosocial risk factors and Alzheimer's disease: the associative effect of depression, sleep disturbance, and anxiety.
Aging Ment Health,2018,22(12):1577-1584
|
CSCD被引
4
次
|
|
|
|
|
10.
Sun Q. Clinical profile of chinese long-term Parkinson's disease survivors with 10 years of disease duration and beyond.
Aging Dis,2018,9(1):8-16
|
CSCD被引
2
次
|
|
|
|
|
11.
Dieterich W. Microbiota in the gastrointestinal tract.
Med Sci,2018,6(4):116
|
CSCD被引
2
次
|
|
|
|
|
12.
Federici M. Our second genome and the impact on metabolic disorders: why gut microbiome is an important player in diabetes and associated abnormalities.
Acta Diabetol,2019,56(5):491-492
|
CSCD被引
1
次
|
|
|
|
|
13.
Menard C. Immune and neuroendocrine mechanisms of stress vulnerability and resilience.
Neuropsychopharmacology,2017,42(1):62-80
|
CSCD被引
10
次
|
|
|
|
|
14.
Liu L. Herbal medicine for anxiety, depression and insomnia.
Curr Neuropharmacol,2015,13(4):481-493
|
CSCD被引
8
次
|
|
|
|
|
15.
Vanuytsel T. Psychological stress and corticotropin-releasing hormone increase intestinal permeability in humans by a mast cell-dependent mechanism.
Gut,2014,63(8):1293-1299
|
CSCD被引
21
次
|
|
|
|
|
16.
Haddad-Tovolli R. Development and function of the blood-brain barrier in the context of metabolic control.
Front Neurosci,2017,11:224
|
CSCD被引
3
次
|
|
|
|
|
17.
Schoultz I. Cellular and molecular therapeutic targets in inflammatory bowel disease-focusing on intestinal barrier function.
Cells,2019,8(2):193
|
CSCD被引
12
次
|
|
|
|
|
18.
Rahman M T. IFN-g, IL-17A, or zonulin rapidly increase the permeability of the blood-brain and small intestinal epithelial barriers: relevance for neuro-inflammatory diseases.
Biochem Biophys Res Commun,2018,507(1/4):274-280
|
CSCD被引
8
次
|
|
|
|
|
19.
Cui B. Effects of chronic noise exposure on the microbiome-gut-brain axis in senescence-accelerated prone mice: implications for Alzheimer's disease.
J Neuroinflamm,2018,15:190
|
CSCD被引
8
次
|
|
|
|
|
20.
Stevens B R. Increased human intestinal barrier permeability plasma biomarkers zonulin and FABP2 correlated with plasma LPS and altered gut microbiome in anxiety or depression.
Gut,2018,67(8):1555-1557
|
CSCD被引
28
次
|
|
|
|
|
了解气象卫星更多信息，请访问