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Two new ursane-type nortriterpenes from Lonicera macranthoides and their iNOS-inhibitory activities

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Mei Yudan 1,2   Zhang Nan 3   Zhang Weiyang 4   Tang Jinshan 1   Zhou Hua 4   Yu Yang 1 *   Yao Xinsheng 1,3 *  
文摘 The flower buds of Lonicera macranthoides (Shan Yin-Hua), represent an important traditional Chinese medicine and food ingredient. A phytochemical investigation of the 70% EtOH extract of the flower buds of L. macranthoides resulted in the isolation of 12 triterpenoids (1-12), including two new ursane-type nortriterpenes, 2α, 24-dihydroxy-23-nor-ursolic acid (1) and 2α, 4α-dihydroxy-23-nor-ursolic acid (2). Their structures were established by multiple spectroscopic methods and comparison with literature data. All isolated compounds were evaluated for their anti-inflammatory effects in LPS-activated RAW264.7 cells. Compounds 1 and 2 exhibited inhibitory effects on iNOS at the concentration of 30 μmol·L~(-1).
来源 Chinese Journal of Natural Medicines ,2019,17(1):27-32 【核心库】
DOI 10.3724/SP.J.1009.2019.00027
关键词 Lonicerae Flos ; Lonicera macranthoides ; Ursane-type nortriterpenes ; Anti-inflammation ; iNOS
地址

1. Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy , Jinan University(Guangdong), Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Guangzhou, 510632  

2. XiangXue Academician workstation, Xiangxue Pharmaceutical Co., Ltd., Guangzhou, 510663  

3. College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016  

4. Macau University of Science and Technology and (Macau University of Science and Technology, State Key Laboratory of Quality Research in Chinese Medicine Faculty of Chinese Medicine, Macau, 999078

语种 英文
文献类型 研究性论文
ISSN 2095-6975
学科 中国医学
基金 国家自然科学基金 ;  Science and Technology Planning Project of Guangdong Province
文献收藏号 CSCD:6416308

参考文献 共 24 共2页

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引证文献 2 篇

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2 Liu Xuqiang Flowers: precious food and medicine resources Food Science and Human Wellness,2023,12(4):1020-1052
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