Ring-restricted N-nitrosated rhodamine as a green-light triggered, orange-emission calibrated and fast-releasing nitric oxide donor
查看参考文献20篇
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文摘
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Nitric oxide (NO) donors are versatile tools for nitric oxide biology. The biological response of NO is dependent on the transient concentration and the sustained duration. N-Nitrosated rhodamines are photo-triggered and photo-calibrated NO donors. We recently discovered that suppression of the dihedral angle between the N-nitroso fragment with the rhodamine scaffold facilitates NO release. Inspired by this discovery, we developed a fast-releasing NO donor (NOD575) suitable for biological applications, e.g., the pulmonary arterial smooth muscle cells (PASMCs). |
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来源
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Chinese Chemical Letters
,2018,29(10):1497-1499 【核心库】
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DOI
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10.1016/j.cclet.2018.08.019
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关键词
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NO donor
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Photo-trigger
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Photo-calibrate
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Platelet aggregation inhibition
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Antimicrobial
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地址
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1.
School of Pharmacy, East China University of Science and Technology, Shanghai Key Laboratory of Chemical Biology, Shanghai, 200237
2.
Guangxi Scientific Research Center of Traditional Chinese Medicine, Guangxi University of Chinese Medicine, Nanning, 530200
3.
Shenyang Sinochem Agrochemicals R&D Co., Ltd., State Key Laboratory of the Discovery and Development of Novel Pesticide, Shenyang, 110021
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East China University of Science and Technology, State Key Laboratory of Bioreactor Engineering, Shanghai, 200237
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语种
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英文 |
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文献类型
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研究性论文 |
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ISSN
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1001-8417 |
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学科
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化学 |
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基金
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financially supported by the National Natural Science Foundation of China
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the Fundamental Research Funds for the Central Universities
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文献收藏号
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CSCD:6346033
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