Correlation between Sex and Prognosis of Acute Aortic Dissection in the Chinese Population
查看参考文献30篇
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文摘
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Background: The prevalence, presentation, management, and prognosis of coronary heart disease differ according to sex. Greater understanding on the differences between men and women with acute aortic dissection (AAD) is needed. We aimed to investigate whether sex disparities are found in patients with AAD, and to study sex differences in complications, mortality in-hospital, and long-term. Methods: We included 884 patients enrolled in our institute between June 2002 and May 2016. Considering psychosocial factors, treatments, and the outcomes in men versus those in women with AAD, we explored the association of sex with psychosocial characteristics and mortality risk. For categorical variables, significant differences between groups were assessed with the Chi-square test or Fisher's exact test, and continuous parameters were assessed with Student's t-test. Univariate and stratified survival statistics were computed using Kaplan-Meier analysis. Results: A total of 884 patients (76.1 % male, mean age 51.4 ± 11.8 years) were included in this study. There were fewer current smokers in female compared with male (17.5% vs. 67.2%, χ~2 = 160.06,P < 0.05). The percentage of men who reported regular alcohol consumption was significantly higher than that in women (40.6% vs. 3.8%,χ~2 = 100.18,P< 0.05). About 6.2% (55 of 884) of patients with AAD died before vascular or endovascular surgery was performed, 34.4% (304 of 884) of patients underwent surgical procedures, and 52.7% (466 of 884) and 12.8% (113 of 884) of patients received endovascular treatment and medication. Postoperative mortality similar (6.0% vs. 5.6%, respectively, χ~2 = 0.03,P = 0.91) between men and women. Follow-up was completed in 653 of 829 patients (78.8%). Adjustment for age, history of coronary disease, hypertension, smoking and drinking, Type A and use of beta-blocker, angiotensin II receptor blockers, angiotensin converting enzyme (ACE) inhibitor, calcium-channel blockers and statins by multivariate logistic regression analysis suggested that age (odds ratios [ORs], 1.04; 95% confidence interval [CI], 1.01-1.07; P < 0.05), using of calcium-channel blockers (OR, 0.37; 95% CI, 0.18-0.74;P < 0.05), at discharge were independent predictors of late mortality, ACE inhibitors (OR, 1.91; 95% CI, 1.03-3.54; P = 0.04) was independent risk factor of late mortality. Conclusions: In Chinese with AAD, sex is not independently associated with long-term clinical outcomes. Age, the intake of calcium-channel blockers at discharge might help to improve long-term outcomes. |
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来源
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Chinese Medical Journal
,2018,131(12):1430-1435 【核心库】
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DOI
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10.4103/0366-6999.233943
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关键词
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Aortic Dissection
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Prognosis
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Sex
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地址
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Department of Cardiology, Institute of Cardiovascular Research, General Hospital of Shenyang Military Region, Liaoning, Shenyang, 110016
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语种
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英文 |
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文献类型
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研究性论文 |
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ISSN
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0366-6999 |
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学科
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医药、卫生 |
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基金
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supported by the grants from the National Key Project of Research and Development Plan during the Thirteenth Five-year Plan Period
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the Construction Program of National Clinical Priority Speciality
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文献收藏号
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CSCD:6266042
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参考文献 共
30
共2页
|
|
1.
He R X. Safety and Necessity of Antiplatelet Therapy on Patients Underwent Endovascular Aortic Repair with Both Stanford Type B Aortic Dissection and Coronary Heart Disease.
Chin Med J,2017,130:2321-2325
|
CSCD被引
4
次
|
|
|
|
|
2.
Bossone E. Acute aortic syndromes: Diagnosis and management, an update.
Eur Heart J,2017,30:1-15
|
CSCD被引
28
次
|
|
|
|
|
3.
Zhou Q. Association of Plasma Pentraxin-3 Levels on Admission with In-hospital Mortality in Patients with Acute Type A Aortic Dissection.
Chin Med J,2016,129:2589-2595
|
CSCD被引
1
次
|
|
|
|
|
4.
Li D. Significance of the thrombo-inflammatory status-based novel prognostic score as a useful predictor for in-hospital mortality of patients with type B acute aortic dissection.
Oncotarget,2017,8:79315-79322
|
CSCD被引
2
次
|
|
|
|
|
5.
Takagi H. Meta-analysis of circadian variation in the onset of acute aortic dissection.
Am J Cardiol,2017,120:1662-1666
|
CSCD被引
4
次
|
|
|
|
|
6.
Bachet J. Prognostic significance of early aortic remodeling in acute uncomplicated type B aortic dissection and intramural hematoma: Tell us what to do.
J Thorac Cardiovasc Surg,2017,154:1171-1172
|
CSCD被引
1
次
|
|
|
|
|
7.
Guo J. A case report of Takayasu arteritis with aortic dissection as initial presentation.
Medicine (Baltimore),2017,96:e8610
|
CSCD被引
1
次
|
|
|
|
|
8.
Krol E. Uncomplicated acute type B aortic dissection: Selection guidelines for TEVAR.
Ann Vasc Dis,2017,10:pii: ra. 17-00061
|
CSCD被引
3
次
|
|
|
|
|
9.
Matsushita A. Impact of initial aortic diameter and false-lumen area ratio on type B aortic dissection prognosis.
Interact Cardiovasc Thorac Surg,2017,26:176-182
|
CSCD被引
2
次
|
|
|
|
|
10.
Elsayed R S. Acute type A aortic dissection.
Cardiol Clin,2017,35:331-345
|
CSCD被引
12
次
|
|
|
|
|
11.
Zhu T. Early outcomes of the conformable stent graft for acute complicated and uncomplicated type B aortic dissection.
J Vasc Surg,2017,66:1644-1652
|
CSCD被引
3
次
|
|
|
|
|
12.
Sadowski M. Higher mortality in women after ST-segment elevation myocardial infarction in very young patients.
Arch Med Sci,2013,9:427-433
|
CSCD被引
1
次
|
|
|
|
|
13.
Nienaber C A. Gender-related differences in acute aortic dissection.
Circulation,2004,109:3014-3021
|
CSCD被引
26
次
|
|
|
|
|
14.
Fukui T. Gender differences in acute type a aortic dissection.
J Thorac Cardiovasc Surg,2016,151:1772-1773
|
CSCD被引
1
次
|
|
|
|
|
15.
Speir A. Gender differences in patients undergoing surgery for acute type A aortic dissection: Is there really a glass ceiling?.
J Thorac Cardiovasc Surg,2015,150:587-588
|
CSCD被引
1
次
|
|
|
|
|
16.
Takeshita S. Angiotensin-converting enzyme inhibitors reduce long-term aortic events in patients with acute type B aortic dissection.
Circ J,2008,72:1758-1761
|
CSCD被引
2
次
|
|
|
|
|
17.
Hackam D G. Angiotensin-converting enzyme inhibitors and aortic rupture: A population-based case-control study.
Lancet,2006,368:659-665
|
CSCD被引
10
次
|
|
|
|
|
18.
Suzuki T. Type-selective benefits of medications in treatment of acute aortic dissection (from the International Registry of Acute Aortic Dissection [IRAD]).
Am J Cardiol,2012,109:122-127
|
CSCD被引
8
次
|
|
|
|
|
19.
Kanai T. Navl.7 sodium channel-induced Ca2+ influx decreases tau phosphorylation via glycogen synthase kinase-3beta in adrenal chromaffin cells.
Neurochem Int,2009,54:497-505
|
CSCD被引
4
次
|
|
|
|
|
20.
Alvarez L. Electrophysiologic assessment of calcium channel blockers in transplanted hearts: An experimental study.
J Electrocardiol,1998,31:51-56
|
CSCD被引
2
次
|
|
|
|
|
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