LncRNAs in DNA damage response and repair in cancer cells
查看参考文献107篇
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文摘
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In order to maintain integrity of the genome, eukaryotic cells develop a complex DNA damage/ repair response network, which can induce cell cycle arrest, apoptosis, or DNA repair. Chemo- and radiation therapies, which act primarily through the induction of DNA damage, are the most commonly used therapies for cancer. Impairment in the DNA damage response and repair system that protect cells from persistent DNA damage can affect the therapeutic efficacy of cancer. To date, accumulating evidence has suggested that long non-coding RNAs (IncRNAs) are involved in the regulation of the DNA damage/repair network. LncRNAs have been demonstrated to be master regulators of the genome at the transcriptional and post-transcriptional levels and play a key role in many physiological and pathological processes of cells. In this review, we will discuss the function of IncRNAs in regulating the cellular response to DNA damage. |
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来源
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Acta Biochimica et Biophysica Sinica
,2018,50(5):433-439 【核心库】
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DOI
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10.1093/abbs/gmy022
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关键词
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DNA damage response
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apoptosis
;
cell cycle
;
cancer
;
IncRNA
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地址
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1.
Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya Medical School, Central South University, Changsha, 410013
2.
Department of Medical Microbiology, Immunology & Cell Biology, Simmons Cancer Institute, Southern Illinois University School of Medicine, USA, Springfield, 62794
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语种
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英文 |
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文献类型
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研究性论文 |
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ISSN
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1672-9145 |
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基金
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supported in part by the grants from the National Natural Science Foundation of China
;
湖南省自然科学基金
;
the Scientific Research Foundation of the Health and Family Planning Commission of Hunan Province
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文献收藏号
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CSCD:6252625
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参考文献 共
107
共6页
|
|
1.
Bartek J. DNA damage checkpoints: from initiation to recovery or adaptation.
Curr Opin Cell Biol,2007,19:238-245
|
被引
10
次
|
|
|
|
|
2.
Ciccia A. The DNA damage response: making it safe to play with knives.
Mol Cell,2010,40:179-204
|
被引
103
次
|
|
|
|
|
3.
Kumar R. Chromatin modifications and the DNA damage response to ionizing radiation.
Front Oncol,2012,2:214
|
被引
3
次
|
|
|
|
|
4.
Jackson S P. The DNA-damage response in human biology and disease.
Nature,2009,461:1071-1078
|
被引
127
次
|
|
|
|
|
5.
Brown J S. Targeting DNA repair in cancer: beyond PARP inhibitors.
Cancer Discov,2017,7:20-37
|
被引
13
次
|
|
|
|
|
6.
Yap T A. Poly(ADP-ribose) polymerase (PARP) inhibitors: exploiting a synthetic lethal strategy in the clinic.
CA Cancer J Clin,2011,61:31-49
|
被引
10
次
|
|
|
|
|
7.
Tessitore A. MicroRNAs in the DNA damage/repair network and cancer.
Int J Genomics,2014,2014:820248
|
被引
2
次
|
|
|
|
|
8.
Murai J. Targeting DNA repair and replication stress in the treatment of ovarian cancer.
Int J Clin Oncol,2017,22:619-628
|
被引
2
次
|
|
|
|
|
9.
Khorkova O. Basic biology and therapeutic implications of IncRNA.
Adv Drug Deliv Rev,2015,87:15-24
|
被引
13
次
|
|
|
|
|
10.
Chen Q N. Long non-coding RNAs in anticancer drug resistance.
Oncotarget,2017,8:1925-1936
|
被引
8
次
|
|
|
|
|
11.
Cadet J. DNA base damage by reactive oxygen species, oxidizing agents, and UV radiation.
Cold Spring Harb Perspect Biol,2013,5:a12559
|
被引
17
次
|
|
|
|
|
12.
Lukas J. More than just a focus: the chromatin response to DNA damage and its role in genome integrity maintenance.
Nat Cell Biol,2011,13:1161-1169
|
被引
16
次
|
|
|
|
|
13.
Li J. DNA double-strand break repair: a tale of pathway choices.
Acta Biochim Biophys Sin (Shanghai),2016,48:641-646
|
被引
4
次
|
|
|
|
|
14.
Thomasova D. Cell cycle control in the kidney.
Nephrol, Dial, Transplant,2015,30:1622-1630
|
被引
4
次
|
|
|
|
|
15.
Zhu S. DNA damage response in cisplatin-induced nephrotoxicity.
Arch Toxicol,2015,89:2197-2205
|
被引
10
次
|
|
|
|
|
16.
Roos W P. DNA damage-induced cell death: from specific DNA lesions to the DNA damage response and apoptosis.
Cancer Lett,2013,332:237-248
|
被引
27
次
|
|
|
|
|
17.
Kemp M G. The DNA damage response kinases DNA-dependent protein kinase (DNA-PK) and ataxia telangiectasia mutated (ATM) are stimulated by bulky adduct-containing DNA.
J Biol Chem,2011,286:19237-19246
|
被引
1
次
|
|
|
|
|
18.
Uziel T. Requirement of the MRN complex for ATM activation by DNA damage.
EMBO J,2003,22:5612-5621
|
被引
15
次
|
|
|
|
|
19.
San Filippo J. Mechanism of eukaryotic homologous recombination.
Annu Rev Biochem,2008,77:229-257
|
被引
31
次
|
|
|
|
|
20.
Shen H. ARRB1 enhances the chemosensitivity of lung cancer through the mediation of DNA damage response.
Oncol Rep,2017,37:761-767
|
被引
1
次
|
|
|
|
|
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