Differential expression of Kindlin-1 and Kindlin-2 correlates with esophageal cancer progression and epidemiology
查看参考文献27篇
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文摘
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Esophageal cancer (EC) is one of the most lethal malignancies in China, but the etiology and risk factors remain unclear. The integrin-interacting proteins Kindlin-1 and Kindlin-2 are focal adhesion molecules that activate transmembrane receptor integrins and regulate tumor cell growth, invasion, and metastasis. Here, we report that Kindlin-1 and Kindlin-2 are differentially expressed among Chinese EC patients. For this, Kindlin-1 and Kindlin-2 expression was evaluated in 220 EC patients by immunohistochemistry (IHC) and found to be correlated with the EC progression, along with a variety of epidemiologic parameters, including smoking, family EC history, and EC invasion status. Moreover, data downloaded from the Oncomine database revealed that both Kindlin-1 and Kindlin-2 were upregulated in ECs compared with normal esophageal tissues; although Kindlin-1 was highly expressed in well-differentiated tumors, whereas Kindlin-2 was more prevalent in poorly differentiated tumors. Collectively, these data suggest that Kindlin-1 may inhibit, while Kindlin-2 may promote, EC progression. This study, for the first time, linked the expression of Kindlin-1 and Kindlin-2 with EC family genetic background and living habits, which may help further our understanding of the various causes of EC. |
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来源
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Science China. Life Sciences
,2017,60(11):1214-1222 【核心库】
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DOI
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10.1007/s11427-016-9044-5
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关键词
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Kindlin-1
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Kindlin-2
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esophageal cancer
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epidemiology
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地址
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1.
Department of Anatomy, Histology and Embryology, Peking University Health Science Center, Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education;;State Key Laboratory of Natural and Biomimetic Drugs, Beijing, 100191
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Institute of Cardiovascular Research, Peking University Health Science Center, Beijing, 100191
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National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, State Key Laboratory of Molecular Oncology, Beijing, 100021
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语种
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英文 |
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文献类型
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研究性论文 |
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ISSN
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1674-7305 |
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学科
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肿瘤学 |
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基金
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supported by the Ministry of Science and Technology of China
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国家自然科学基金
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北京市自然科学基金
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the 111 Project of the Ministry of Education, Peking University
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a Leading Academic Discipline Project of Beijing Education Bureau to Hongquan Zhang
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文献收藏号
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CSCD:6150316
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