Immunological and virological characteristics of human immunodeficiency virus type 1 superinfection: implications in vaccine design
查看参考文献80篇
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文摘
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Superinfection is frequently detected among individuals infected by human immunodeficiency virus type I (HIV-1). Superinfection occurs at similar frequencies at acute and chronic infection stages but less frequently than primary infection. This observation indicates that the immune responses elicited by natural HIV-1 infection may play a role in curb of superinfection; however, these responses are not sufficiently strong to completely prevent superinfection. Thus, a successful HIV-1 vaccine likely needs to induce more potent and broader immune responses than those elicited by primary infection. On the other hand, potent and broad neutralization responses are more often detected after superinfection than during monoinfection. This suggests that broadly neutralizing antibodies are more likely induced by sequential immunization of multiple different immunogens than with only one form of envelope glycoprotein immunogens. Understanding why the protection from superinfection by immunity induced by primary infection is insufficient and if superinfection can lead to cross-reactive immune responses will be highly informative for HIV-1 vaccine design. |
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来源
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Frontiers of Medicine
,2017,11(4):480-489 【核心库】
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DOI
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10.1007/s11684-017-0594-8
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关键词
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human immunodeficiency virus type I
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superinfection
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incidence
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immune response
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地址
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1.
Department of Laboratory Medicine, The First Affiliated Hospital, China Medical University, Key Laboratory of AIDS Immunology of National Health and Family Planning Commission, Shenyang, 110001
2.
School of Life Sciences, Jilin University, National Engineering Laboratory for AIDS Vaccine, Changchun, 130012
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语种
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英文 |
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文献类型
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研究性论文 |
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ISSN
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2095-0217 |
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学科
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医药、卫生 |
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基金
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国家自然科学基金
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Program for JLU Science and Technology Innovative Research Team
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a grant from NIAID of NIH
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文献收藏号
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CSCD:6141297
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参考文献 共
80
共4页
|
|
1.
Allen T M. HIV-1 superinfection.
J Allergy Clin Immunol,2003,112(5):829-835
|
CSCD被引
1
次
|
|
|
|
|
2.
Smith D M. HIV superinfection.
J Infect Dis,2005,192(3):438-444
|
CSCD被引
2
次
|
|
|
|
|
3.
Waters L. HIV-1 superinfection.
Curr Opin Infect Dis,2012,25(1):42-50
|
CSCD被引
1
次
|
|
|
|
|
4.
Ramos A. Intersubtype human immunodeficiency virus type 1 superinfection following seroconversion to primary infection in two injection drug users.
J Virol,2002,76(15):7444-7452
|
CSCD被引
3
次
|
|
|
|
|
5.
Manigart O. HIV-1 superinfections in a cohort of commercial sex workers in Burkina Faso as assessed by an autologous heteroduplex mobility procedure.
AIDS,2004,18(12):1645-1651
|
CSCD被引
1
次
|
|
|
|
|
6.
Hu D J. Frequency of HIV-1 dual subtype infections, including intersubtype superinfections, among injection drug users in Bangkok, Thailand.
AIDS,2005,19(3):303-308
|
CSCD被引
1
次
|
|
|
|
|
7.
Smith D M. Lack of neutralizing antibody response to HIV-1 predisposes to superinfection.
Virology,2006,355(1):1-5
|
CSCD被引
1
次
|
|
|
|
|
8.
Redd A D. Identification of HIV superinfection in seroconcordant couples in Rakai, Uganda, by use of next-generation deep sequencing.
J Clin Microbiol,2011,49(8):2859-2867
|
CSCD被引
3
次
|
|
|
|
|
9.
Redd A D. Rates of HIV-1 superinfection and primary HIV-1 infection are similar in female sex workers in Uganda.
AIDS,2014,28(14):2147-2152
|
CSCD被引
1
次
|
|
|
|
|
10.
Redd A D. The rates of HIV superinfection and primary HIV incidence in a general population in Rakai, Uganda.
J Infect Dis,2012,206(2):267-274
|
CSCD被引
2
次
|
|
|
|
|
11.
Altfeld M. HIV-1 superinfection despite broad CD8~+ T-cell responses containing replication of the primary virus.
Nature,2002,420(6914):434-439
|
CSCD被引
2
次
|
|
|
|
|
12.
Basu D. HIV-1 subtype C superinfected individuals mount low autologous neutralizing antibody responses prior to intrasubtype superinfection.
Retrovirology,2012,9(1):76
|
CSCD被引
1
次
|
|
|
|
|
13.
Basu D. Low antibody-dependent cellular cytotoxicity responses in Zambians prior to HIV-1 intrasubtype C superinfection.
Virology,2014,462/463:295-298
|
CSCD被引
1
次
|
|
|
|
|
14.
Blish C A. Human immunodeficiency virus type1 superinfection occurs despite relatively robust neutralizing antibody responses.
J Virol,2008,82(24):12094-12103
|
CSCD被引
1
次
|
|
|
|
|
15.
Sun M. Functional effector memory T cells contribute to protection from superinfection with heterologous simian immunodeficiency virus or simian-human immunodeficiency virus isolates in Chinese rhesus macaques.
Arch Virol,2017,162(5):1211-1221
|
CSCD被引
1
次
|
|
|
|
|
16.
Cortez V. The broad neutralizing antibody responses after HIV-1 superinfection are not dominated by antibodies directed to epitopes common in single infection.
PLoS Pathog,2015,11(7):e1004973
|
CSCD被引
3
次
|
|
|
|
|
17.
Powell R L. Infection by discordant strains of HIV-1 markedly enhances the neutralizing antibody response against heterologous virus.
J Virol,2010,84(18):9415-9426
|
CSCD被引
2
次
|
|
|
|
|
18.
Cortez V. HIV-1 superinfection in women broadens and strengthens the neutralizing antibody response.
PLoS Pathog,2012,8(3):e1002611
|
CSCD被引
4
次
|
|
|
|
|
19.
Jost S. A patient with HIV-1 superinfection.
N Engl J Med,2002,347(10):731-736
|
CSCD被引
3
次
|
|
|
|
|
20.
van der Kuyl A C. Identifying HIV-1 dual infections.
Retrovirology,2007,4(1):67
|
CSCD被引
1
次
|
|
|
|
|
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