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强化运动、维生素D和钙剂补充对绝经后女性肌力及骨折的影响
Effects of Enhanced Exercise and Combined Vitamin D and Calcium Supplementation on Muscle Strength and Fracture Risk in Postmenopausal Chinese Women

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薛瑜 1   胡莹莹 2   王鸥 1   王春艳 3   韩桂艳 4   沈蔷 5   邓红月 5   姜艳 1   李梅 1   夏维波 1   邢小平 1 *   徐苓 6  
文摘 目的观察强化运动、不同维生素D制剂和钙剂补充对绝经后骨质疏松高危人群肌力及骨折的影响。方法纳入北京市东城区绝经后女性614名,具有骨质疏松高危因素,随机分为4组:(1)A组(n=173):对照组;(2)B组(n=171):强化运动组;(3)C组(n=139):给予元素钙600 mg/d+普通维生素D 800 U/d;(4)D组(n=131):给予元素钙600 mg/d+ 25羟基维生素D(25OHD)0.25 μg/d。随访2年,测定基线、随访1年及2年肌力,测定基线及随访2年骨转换指标;记录跌倒及新发骨折次数。结果92.6%的受试者基线血清25OHD<50 nmol/L。与基线水平比较,A组在随访2年时左手握力(t=-3.252,P=0.001)较基线显著降低,B组1年时右手握力明显下降(t=2.460,P=0.015),C组1年时左手握力显著升高(t=-2.051,P=0.043),D组2年随访中双手握力均无统计学变化(P均>0.05)。随访2年时,A(t=-2.962,P=0.004)、B(t=-2.888,P=0.005)、C组(t=-2.441,P=0.016))血清Ⅰ型前胶原氨基末端前肽水平显著高于基线,B(t=2.285,P=0.024)、D组(t=2.596,P=0.011)Ⅰ型胶原交联羧基末端肽水平显著低于基线。结论强化运动及补充钙和25OHD可能有利于维持改善绝经后女性肌力,补充钙和维生素D可能短期内改善绝经后女性肌力。
其他语种文摘 To observe the effects of enhanced exercise and combined vitamin D and calcium supplementation on muscular strength and fracture occurrence in postmenopausal women with a high risk of osteoporosis.Methods Totally 614 postmenopausal women at high risk factors of osteoporosis were enrolled in Dongcheng district of Beijing and randomized into four groups:group A(control group,n=173),group B(regular Tai Chi exercise,n=171),group C(calcium 600 mg/d+VitD_3 800 U/d,n=139),and group D[calcium 600 mg/d+25 hydroxyl vitamin D(25OHD) 0.25 μg/d,n=131].Muscular strength was measured at baseline and one and two years after intervention.Bone turnover markers were measured at baseline and during the two-year follow-up.Falls and fractures were recorded.Results The incidence of 25OHD<50 nmol/L was approximately 92.6%.During the follow-up,the left grip strength decreased significantly two years after intervention(t=-3.252,P=0.001)in group A.Right grip strength decreased significantly in group B(t=2.460,P=0.015)while left grip strength improved significantly in group C(t=-2.051,P=0.043)one year after intervention.In group D,muscular strength in both 12-month and 24-month did not change compared with baseline(both P>0.05).Furthermore,serum procollagen type I N-terminal propeptide elevated significantly in group A(t=-2.962,P=0.004),group B(t=-2.888,P=0.005),and group C(t=-2.441,P=0.016),whereas β-C-terminal telopeptide of type I collagen decreased significantly in group B(t=2.285,P=0.024)and group D(t=2.596,P=0.011)two years after intervention.Conclusion Enhanced exercise and combined calcium vitamin D supplementation may help sustain muscle strength in postmenopausal women,while calcium and vitamin D supplementation may improve muscular strength within a short period of time.
来源 中国医学科学院学报 ,2017,39(3):345-351 【核心库】
DOI 10.3881/j.issn.1000-503x.2017.03.008
关键词 维生素D ; 绝经后女性 ; 强化运动 ; 肌力 ; 骨折
地址

1. 中国医学科学院北京协和医学院北京协和医院内分泌科, 国家卫生和计划生育委员会内分泌重点实验室, 北京, 100730  

2. 中国医学科学院北京协和医学院北京协和医院检验科, 北京, 100730  

3. 航空总医院内分泌科, 北京, 100012  

4. 北京市东城区卫生服务管理中心, 北京, 100010  

5. 北京市东城区社区卫生服务管理中心, 北京, 100010  

6. 中国医学科学院北京协和医学院北京协和医院妇产科, 北京, 100730

语种 中文
文献类型 研究性论文
ISSN 1000-503X
学科 内科学
基金 国家科技支撑计划项目 ;  国家自然科学基金青年基金 ;  国家自然科学基金面上项目 ;  国家临床重点专科建设项目
文献收藏号 CSCD:6021057

参考文献 共 16 共1页

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引证文献 2 篇

1 王敬博 维生素D 对预防跌倒和降低骨质疏松骨折的作用 中国矫形外科杂志,2018,26(8):724-727
CSCD被引 3 次

2 李颖 中国居民钙摄入对人体健康影响的思考 中华预防医学杂志,2022,56(4):533-540
CSCD被引 4 次

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