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Association of endothelial nitric oxide synthase polymorphisms with an increased risk of erectile dysfunction

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Gao Lei 1   Zhao Zhifeng 1   Guo Fengfu 1   Liu Yan 2 *   Guo Jianhua 3   Zhao Yang 3   Wang Zhong 3  
文摘 The purpose of our meta-analysis is to examine the associations between three single nucleotide polymorphisms of endothelial nitric oxide synthase (eNOS) gene, G894T, intron 4 and T-786C, and the risk of erectile dysfunction. An electronic database search was performed to identify case-control studies reporting the association between single nucleotide polymorphisms of eNOS gene and erectile dysfunction. Stringent inclusion and exclusion criteria were employed to select high-quality studies for this meta-analysis. Comprehensive Meta-analysis 2.0 software (Biostat Inc., Englewood, New Jersey, USA) was used for statistical analysis of the data extracted from the selected studies. From the initial 203 articles retrieved from database search,this meta-analysis finally selected 12 high-quality case-control studies that conformed to our inclusion criteria. The 12 studies contained a total of 1962 patients with erectile dysfunction and 1752 healthy controls. The results of our meta-analysis showed that G894T correlated with an increased risk erectile dysfunction under both the allele and dominant models (allele: OR = 1.556, 95% CI = 1.064-2.275, P= 0.023; dominant: OR = 1.613, 95% CI = 1.050-2.476, P= 0.029). A similar association was found between T-786C and erectile dysfunction under the allele model (OR = 1.679, 95% CI = 1.341-2.102, P< 0.001), but not under the dominant model(all P > 0.05). Our meta-analysis showed that the two single nucleotide polymorphisms in eNOS gene, G894T and T-786C, are strongly associated with the risk of erectile dysfunction.
来源 Asian Journal of Andrology ,2017,19(3):330-337 【核心库】
DOI 10.4103/1008-682x.163300
关键词 endothelial nitric oxide synthase ; erectile dysfunction ; G894T ; intron 4 ; meta-analysis ; single nucleotide polymorphism
地址

1. Department of Urinary Surgery, Linyi People's Hospital, Linyi, 276000  

2. Department of Urinary Surgery, Linyi Cancer Hospital, Linyi, 276000  

3. Department of Urology and Andrology, Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200011

语种 英文
文献类型 研究性论文
ISSN 1008-682X
学科 医药、卫生
文献收藏号 CSCD:5978518

参考文献 共 45 共3页

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