神经营养因子的局限与雷公藤类天然药物的机遇
Limitations of neurotrophic factor and opportunities of triptolide natural medicine
查看参考文献21篇
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文摘
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神经营养因子在神经元的发育、营养、存活、凋亡及损伤后修复中扮演着重要角色。然而,不易通过血脑屏障的性质限制了其临床应用。天然药物雷公藤内酯醇可促进神经营养因子的分泌,且具有分子量小、易通过血脑屏障的分子特征,引起了国内外研究机构的广泛关注。文章将对神经营养因子在治疗神经疾病的局限以及雷公藤内酯醇及其衍生物所带来的研究机遇做一综述,为进一步探索天然植物药雷公藤对神经系统疾病的治疗提供新的视角或新途径。 |
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其他语种文摘
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Neurotrophic factor plays an important role in the development, nutrition, survival and apoptosis of neurons, as well as in the post-injury repair. However, neurotrophic factor is not capable to cross the blood-brain barrier, which limits its clinical application. Triptolide, a small molecule extract from the traditional Chinese herb, Tripterygium wilfordii Hook. f, has been shown to promote the secretion of neurotrophic factor. Owing to its lipophilic characteristic, small molecular weight, and easy to pass through the blood-brain barrier, the therapeutic effect of triptolide on neurological diseases has attracted widespread attention. This article will review the limitations of neurotrophic factor in the treatment of neurological diseases and the research opportunities brought by triptolide and its derivatives, in order to provide a new perspective for the treatment of neurological diseases by exploring the natural medicine Tripterygium wilfordii Hook. f. |
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来源
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中华中医药杂志
,2017,32(3):1184-1186 【核心库】
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关键词
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神经营养因子
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天然药物
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雷公藤内酯醇
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神经保护作用
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神经退行性疾病
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地址
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1.
汕头大学医学院, 广东, 汕头, 515041
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南方科技大学化学系, 深圳, 518055
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北京大学深圳医院, 深圳, 518036
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语种
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中文 |
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文献类型
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综述型 |
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ISSN
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1673-1727 |
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学科
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中国医学 |
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基金
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深圳市技术创新项目
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文献收藏号
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CSCD:5936777
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21
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