Synthesis, Crystal Structure and PTPs Inhibition of a Zinc(Ⅱ) Complex with N-(4-hydroxybenzyl)-L-serine
查看参考文献25篇
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文摘
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The reaction of the reduced Schiff base HL (N-(4-hydroxybenzyl)-L-serine) with Zn(CH_3COO)_2·2H_2O in aqueous solution afforded [Zn(L)_2]· 3H_2O (I). The complex has been characterized by elemental analysis, FT-IR, powder X-ray diffraction, electrospray ionization mass spectrometry and single-crystal X-ray diffraction. Complex I crystallizes in the orthorhombic system, space group P2_12_12_1, with a = 9.197(2), b = 10.445(2),c = 24.149(5) A, V= 2319.8(8) A~3, Z = 4,C_(20)H_(30)N_2O_(11)Zn, Mr = 539.83,D_c= 1.546 g·cm~3,μ = 1.122 mm~(-1),F(000) = 1128,GOOF= 0.971, the final R = 0.0206 and wR = 0.0506 for 4346 observed reflections (I>2σ(I)). In complex I,each Zn(Ⅱ) ion coordinates with three carboxyl oxygen atoms and two amine nitrogen atoms from three L~-anions, forming a distorted five-coordinated trigonal bipyramidal geometry. Complex I exhibits a 1D wavy chain structure that is extended by hydrogen-bonding interactions to form a supramolecular network. The bioactivity of the complex as a potential PTPs inhibitor in vitro was investigated, displaying potent inhibition against PTP1B (IC_(50), 0.24 μM) and TCPTP (IC_(50), 0.53 μM) with a moderate selectivity. |
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来源
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Chinese Journal of Structural Chemistry
,2017,36(2):316-323 【核心库】
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DOI
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10.14102/j.cnki.0254-5861.2011-1355
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关键词
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zinc(Ⅱ) complex
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N-(4-hydroxybenzyl)-L-serine
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crystal structure
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inhibitory activity
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PTP1B,TCPTP
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地址
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1.
Institute of Molecular Science, Shanxi University, Key Laboratory of Chemical Biology and Molecular Engineering of the Education Ministry, Taiyuan, 030006
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Beijing Synchrotron Radiation Facility, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 100049
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语种
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英文 |
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文献类型
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研究性论文 |
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ISSN
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0254-5861 |
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学科
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化学 |
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基金
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国家自然科学基金
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文献收藏号
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CSCD:5924378
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