天然黄酮类单体化合物抗焦虑作用研究进展
Advanced in studies on anxiolytic effects of natural flavonoids
查看参考文献26篇
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文摘
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焦虑症是严重危害人类健康的常见疾病之一,其发病机制十分复杂,国内外对焦虑症机制的研究多集中在神经递质、神经内分泌和免疫系统。近年来,对天然黄酮类单体化合物抗焦虑作用的研究日渐增多,但研究内容仍较少且不系统,研究方向仅仅涉及几种神经递质。该文将从黄酮类单体化合物抗焦虑的不同作用机制出发,对国内外天然黄酮类单体化合物抗焦虑作用及其机制、构效关系研究进行综述,为黄酮类单体化合物抗焦虑作用机制的深入研究,以及该类药物的开发研制提供理论依据。 |
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其他语种文摘
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Anxiety is one of the most common diseases endangering human health. Its pathogenesis is complex, the studies on the mechanisms of anxiety disorder are concentrated on neurotransmitter, neuroendocrine, immunologic system. Flavonoids are a kind of compounds which possess a variety of physiological activity, used in plenty of diseases. In recent years, researches of natural flavonoids on anti-anxiety were increasing, but contents were incomplete. It was just involved several neurotransmitters in research area. This paper is based on different anxiolytic effect mechanisms and structure-activity relationships of natural flavonoids, summarizing the researches of domestic and foreign, which can serve as a reference for further studies on anxiolytic effects of natural flavonoids. |
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来源
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中国中药杂志
,2016,41(1):38-44 【核心库】
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DOI
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10.4268/cjcmm20160108
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关键词
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天然黄酮类单体化合物
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抗焦虑活性
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抗焦虑机制
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神经递质
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构效关系
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地址
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1.
北京中医药大学中药学院, 北京, 100102
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中国科学院心理研究所, 中国科学院心理健康重点实验室, 北京, 100101
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语种
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中文 |
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文献类型
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综述型 |
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ISSN
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1001-5302 |
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学科
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中国医学 |
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基金
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国家重大科技专项
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文献收藏号
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CSCD:5659284
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参考文献 共
26
共2页
|
|
1.
龚金炎. 黄酮类化合物抗病毒活性的研究进展.
中草药,2008,39(4):623
|
CSCD被引
25
次
|
|
|
|
|
2.
王忠雷. 中药黄酮类抗氧化活性成分研究进展.
世界科学技术-中医药现代化,2013(3):551
|
CSCD被引
5
次
|
|
|
|
|
3.
朱荣鑫. 黄酮类化合物抗肿瘤作用研究进展.
现代药物与临床,2010,25(1):5
|
CSCD被引
12
次
|
|
|
|
|
4.
苏艳杰. 植物黄酮抗骨质疏松作用研究进展.
中国骨质疏松杂志,2014(5):562
|
CSCD被引
7
次
|
|
|
|
|
5.
杨晓露. 甘草总黄酮及其成分体外抗炎活性及机制研究.
中国中药杂志,2013,38(1):99
|
CSCD被引
35
次
|
|
|
|
|
6.
文松. 黄蜀葵花总黄酮苏理活性的研究进展.
世界中医药,2014,9(8):1105
|
CSCD被引
7
次
|
|
|
|
|
7.
王博. 含黄酮类中药的抗癌抗肿瘤作用研究概况.
浙江中医药大学学报,2012(7):838
|
CSCD被引
2
次
|
|
|
|
|
8.
Wolfman C. Possible anxiolytic effects of chrysin, a central benzodiazepine receptor ligand isolated from Passiflora coerulea.
Pharmacol Biochem Behav,1994,47(1):1
|
CSCD被引
8
次
|
|
|
|
|
9.
Viola H. Apigenin, a component of Matricaria recutita flowers, is a central benzodiazepine receptors-ligand with anxiolytic effects.
Planta Med,1995,612:13
|
CSCD被引
1
次
|
|
|
|
|
10.
Dinesh Kumar. Apigenin 7-glucoside from Stachys tibetica Vatke and its anxiolytic effect in rats.
Phytomedicine,2014,21(7):1010
|
CSCD被引
5
次
|
|
|
|
|
11.
Hui K M. Anxiolytic effect of Wogonin, a benzodiazepine receptor ligand isolated from Scutellaria baicalensis Georgi.
Biochem Pharmacol,2002,64(9):1415
|
CSCD被引
5
次
|
|
|
|
|
12.
Rebeca Santos Marques de Carvalho. Involvement of GABAergic non-benzodiazepine sites in the anxiolytic-like and sedative effects of the flavonoid baicalein in mice.
Behav Brain Res,2011,221(1):75
|
CSCD被引
5
次
|
|
|
|
|
13.
Liao J. Anxiolytic-like effects of baicalein and baicalin in the Vogel conflict test in mice.
Eur J Pharmacol,2003,464(2/3):141
|
CSCD被引
2
次
|
|
|
|
|
14.
Coleta M. Assessment of luteolin (3',4',5,7-tetrahydroxyflavone) neuropharmacological activity.
Behav Brain Res,2008,189(1):75
|
CSCD被引
6
次
|
|
|
|
|
15.
Ren L. GABAA receptor subtype selectivity underlying anxiolytic effect of 6-hydroxyflavone.
Biochem Pharmacol,2010,79(5):1337
|
CSCD被引
2
次
|
|
|
|
|
16.
Ishola Ismail O. Antidepressant and anxiolytic effects of amentoflavone isolated from Cnestis ferruginea in mice.
Pharmacol Biochem Behav,2012,103(12):322
|
CSCD被引
5
次
|
|
|
|
|
17.
Liu J. GABA and 5-HT systems are implicated in the anxiolytic-like effect of spinosin in mice.
Pharmacol Biochem Behav,2015,128(1):41
|
CSCD被引
14
次
|
|
|
|
|
18.
Grundmann O. Kaempferol from the leaves of Apocynum venetum possesses anxiolytic activities in the elevated plus maze test in mice.
Phytomedicine,2009,16(1):295
|
CSCD被引
11
次
|
|
|
|
|
19.
Aguirre-Hernandez E. HPLC/MS analysis and anxiolytic-like effect of quercetin and kaempferol flavonoids from Tilia americana var. Mexicana.
J Ethnopharmacol,2010,127(1):91
|
CSCD被引
4
次
|
|
|
|
|
20.
Vissiennon C. Route of administration determines the anxiolytic activity of the flavonols kaempferol, quercetin and myricetin-are they prodrugs.
J Nutr Biochem,2012,7(23):733
|
CSCD被引
1
次
|
|
|
|
|
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