Synthesis and antiproliferative activity of novel 4-substituted-phenoxy-benzamide derivatives
查看参考文献25篇
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文摘
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A series of novel 4-substituted-phenoxy-benzamide derivatives bearing an aryl cycloaliphatic amine moiety were synthesized and evaluated for antiproliferative activity against SW620, HT29 and MGC803 cancer cell lines in vitro. The pharmacological data demonstrated that the majority of target compounds exhibitedmoderate efficacy in HT29 and MGC803 cell lines. Compound 10c showed promising inhibition of hedgehog (Hh) signaling pathway in an Hh-related assay. In addition, the superposition pattern of 10c showed a good fit for a pharmacophoric model generated by Hh inhibitors and provided a basis for further structural optimization. |
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来源
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Chinese Chemical Letters
,2015,26(10):1307-1310 【核心库】
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DOI
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10.1016/j.cclet.2015.06.017
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关键词
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Aryl cycloaliphatic amine
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Antiproliferative activity
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Hedgehog signaling
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地址
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1.
Shenyang Pharmaceutical University, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang, 110016
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The First Affiliated Hospital of Liaoning Medical University, Jinzhou, 121001
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语种
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英文 |
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文献类型
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研究性论文 |
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ISSN
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1001-8417 |
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学科
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化学;化学工业 |
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基金
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supported by Program for Innovative Research Team of the Ministry of Education of China
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Program for Liaoning Innovative Research Team in University
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文献收藏号
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CSCD:5542180
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参考文献 共
25
共2页
|
|
1.
Williams J A. Identification of a small molecule inhibitor of the hedgehog signaling pathway:effects on basal cell carcinoma-like lesions.
Proc. Natl. Acad. Sci. U.S.A,2003,100:4616-4621
|
CSCD被引
8
次
|
|
|
|
|
2.
Mahindroo N. Hedgehog-gli signaling pathway inhibitors as anticancer agents.
J. Med. Chem,2009,52:3829-3845
|
CSCD被引
7
次
|
|
|
|
|
3.
Onishi H. Hedgehog signaling pathway as a therapeutic target in various types of cancer.
Cancer Sci,2011,102:1756-1760
|
CSCD被引
10
次
|
|
|
|
|
4.
Hadden M K. Hedgehog pathway inhibitors:a patent review (2009-present).
Expert Opin. Ther. Pat,2013,23:345-361
|
CSCD被引
4
次
|
|
|
|
|
5.
Pimentel A. New prospects for drug development:the hedgehog pathway revealed. Focus on hematologic malignancies.
Future Oncol,2013,9:681-697
|
CSCD被引
2
次
|
|
|
|
|
6.
Ruch J M. Hedgehog signaling pathway and cancer therapeutics:progress to date.
Drugs,2013,73:613-623
|
CSCD被引
3
次
|
|
|
|
|
7.
Dockendorff C. Macrocyclic hedgehog pathway inhibitors:optimization of cellular activity and mode of action studies.
ACS Med. Chem. Lett,2012,3:808-813
|
CSCD被引
3
次
|
|
|
|
|
8.
Atwood S X. GLI activation by atypical protein kinase C i/l regulates the growth of basal cell carcinomas.
Nature,2013,494:484-488
|
CSCD被引
6
次
|
|
|
|
|
9.
Wang Y. Selective identification of Hedgehog pathway antagonists by direct analysis of smoothened ciliary translocation.
ACS Chem. Biol,2012,7:1040-1048
|
CSCD被引
1
次
|
|
|
|
|
10.
Manetti F. Virtual screening-based discovery and mechanistic characterization of the acylthiourea MRT-10 family as smoothened antagonists.
Mol. Pharmacol,2010,78:658-664
|
CSCD被引
1
次
|
|
|
|
|
11.
Gould S E. Discovery and preclinical development of vismodegib.
Expert Opin. Drug Discov,2014,9:969-984
|
CSCD被引
2
次
|
|
|
|
|
12.
Proctor A E. Vismodegib:an inhibitor of the hedgehog signaling pathway in the treatment of basal cell carcinoma.
Ann. Pharmacother,2014,48:99-106
|
CSCD被引
2
次
|
|
|
|
|
13.
Pan S F. Discovery of NVP-LDE225, a potent and selective smoothened antagonist.
ACS Med. Chem. Lett,2010,1:130-134
|
CSCD被引
16
次
|
|
|
|
|
14.
Zollinger M. Absorption, distribution, metabolism, and excretion (ADME) of ~(14)C-sonidegib (LDE225) in healthy volunteers.
Cancer Chemother. Pharmacol,2014,74:63-75
|
CSCD被引
2
次
|
|
|
|
|
15.
Peukert S. Discovery of NVP-LEQ506, a second-generation inhibitor of smoothened.
Chem. Med. Chem,2013,8:1261-1265
|
CSCD被引
4
次
|
|
|
|
|
16.
Hajipour A R. Application of [Hcpy] HSO_4 bronsted acidic ionic liquid for the synthesis of aryl iodides from aromatic amines.
Org. Prep. Procd. Inter,2011,43:292-296
|
CSCD被引
1
次
|
|
|
|
|
17.
Yang Y H. Design, synthesis and evaluation of novel molecules with a diphenyl ether nucleus as potential antitubercular agents.
Bioorg. Med. Chem. Lett,2012,22:954-957
|
CSCD被引
1
次
|
|
|
|
|
18.
Ding H W. Synthesis and cytotoxic activity of some novel N-pyridinyl-2-(6-phenylimidazo[2,1-b]thiazol-3-yl) acetamide derivatives.
Molecules,2012,17:4703-4716
|
CSCD被引
1
次
|
|
|
|
|
19.
Yang B. Discovery of novel hedgehog antagonists from cell-based screening:isosteric modification of p38 bisamides as potent inhibitors of SMO.
Bioorg. Med. Chem. Lett,2012,22:4907-4911
|
CSCD被引
3
次
|
|
|
|
|
20.
Chen Y B. Design,synthesis and insecticidal activity of novel anthranilic diamides with benzyl sulfide scaffold.
Chin. Chem. Lett,2013,24:673-676
|
CSCD被引
8
次
|
|
|
|
|
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