Danshen (Radix Salviae Miltiorrhizae) reverses renal injury induced by myocardial infarction
查看参考文献28篇
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文摘
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OBJECTIVE: To evaluate the protection of Danshen (Radix Solvioe Miltiorrhizae) (SM) injection in myocardial infarction (Ml) induced renal damage. METHODS: Forty male C57 mice were divided into control group, Ml group and SM group. In Ml group, the left coronary artery was occluded for 8 weeks; the same procedure was used for the SM group, with the additional step of SM (0.2 mL) administered intraperitoneally for 56 days. Before surgery and 8 weeks later, transthoracic echocardiography was performed and urine protein and albumin was measured. At the end of the time, all mice were killed and kidneys removed for reactive oxygen species (ROS) and fibrosis analysis, plasma was collected for blood urea nitrogen and serum creatinine determination. RESULTS: Ml slightly decreased renal function and increased production of ROS, accompanied with renal fibrosis. Administration of SM reduced production of ROS and increased renal function, it also re duced renal fibrosis. CONCLUSION: Ml plays a causal role in renal injury and SM exerts renal-protective effects, probably by its antioxidant activities. |
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来源
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Journal of Traditional Chinese Medicine
,2015,35(3):306-311 【核心库】
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DOI
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10.1016/s0254-6272(15)30102-3
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关键词
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Salvia Miltiorrhiza
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Myocardial infarction
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Reactive oxygen species
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地址
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Department of Pathophysiology, College of Basic Medicine, China Medical University, Shenyang, 110001
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语种
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英文 |
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文献类型
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研究性论文 |
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ISSN
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0255-2922 |
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学科
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细胞生物学;药学 |
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基金
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Supported by the Grants from the National Natural Science Foundation of China (Effects of Membrane-type Matrix Metalloproteinase 1 on Vascular Endothelial Cell Proliferation and Differentiation
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文献收藏号
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CSCD:5449519
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