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Is Early-onset in Major Depression a Predictor of Specific Clinical Features with More Impaired Social Function?

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文摘 Background: Early-onset major depressive disorder (MDD) (EOD) is often particularly malignant due to its special clinical features, accompanying impaired social function, protracted recovery time, and frequent recurrence. This study aimed to observe the effects of age onset on clinical characteristics and social function in MDD patients in Asia. Methods: In total, 547 out-patients aged 18-65 years who were from 13 study sites in five Asian countries were included. These patients had MDD diagnose according to the Diagnostic and Statistical Manual of Mental Disorders, 4~(th) Edition criteria. Clinical features and social function were assessed using Symptom Checklist-90-revised (SCL-90-R) and Sheehan Disability Scale (SDS). Quality of life was assessed by a 36-item Short-form Health Survey (SF-36). Analyses were performed using a continuous or dichotomous (cut-off: 30 years) age-of-onset indicator. Results: Early-onset MDD (EOD, <30 years) was associated with longer illness (P = 0.003), unmarried status (P < 0.001), higher neuroticism (P ≤ 0.002) based on the SCL-90-R, and more limited social function and mental health (P = 0.006, P = 0.007) based on the SF-36 and SDS. The impairment of social function and clinical severity were more prominent at in-patients with younger onset ages. Special clinical features and more impaired social function and quality of life were associated with EOD, as in western studies. Conclusions: EOD often follows higher levels of neuroticism. Age of onset of MDD may be a predictor of clinical features and impaired social function, allowing earlier diagnosis and treatment.
来源 Chinese Medical Journal ,2015,128(6):811-815 【核心库】
DOI 10.4103/0366-6999.152654
关键词 Age Onset ; Asia ; Clinical Features ; Major Depressive Disorder ; Social Function
地址

1. Beijing Huilongguan Hospital, Peking University Teaching Hospital, Beijing, 100096  

2. Peking University Institute of Mental Health, Key Laboratory of Mental Health, Ministry of Mental Health, Beijing, 100191  

3. Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025  

4. Department of Psychiatry, Faculty of Medicine, Chiang Mai University, Thailand, Chiang Mai  

5. Department of Psychiatry, Faculty of Medicine, Asan Medical Center, Korea, Seoul  

6. Department of Psychological Medicine, Faculty of Medicine, University of Malaya, Malaysia, Kuala Lumpur  

7. Institute of Mental Health, Woodbridge Hospital, Singapore  

8. Center for Quantitative Medicine, Office of Clinical Sciences, Duke-National University of Singapore Graduate Medical School, Singapore

语种 英文
文献类型 研究性论文
ISSN 0366-6999
文献收藏号 CSCD:5363394

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