Melatonin lowers edema after spinal cord injury
查看参考文献39篇
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文摘
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Melatonin has been shown to diminish edema in rats. Melatonin can be used to treat spinal cord injury. This study presumed that melatonin could relieve spinal cord edema and examined how it might act. Our experiments found that melatonin (100 mg/kg, i.p.) could reduce the water content of the spinal cord, and suppress the expression of aquaporin-4 and glial ifbrillary acidic protein after spinal cord injury. This suggests that the mechanism by which melatonin alleviates the damage to the spinal cord by edema might be related to the expression of aquaporin-4 and glial ifbrillary acidic protein. |
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来源
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Neural Regeneration Research
,2014,9(24):2205-2210 【核心库】
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DOI
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10.4103/1673-5374.147954
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关键词
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nerve regeneration
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spinal cord injury
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melatonin
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edema
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aquaporin
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glial fibrillary acidic protein
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immunohistochemistry
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western blot assay
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neural regeneration
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地址
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1.
Department of Orthopedic Surgery, Changhai Hospital, the Second Military Medical University, Shanghai
2.
Laboratory of Severe and War-Related Trauma Center, General Hospital of Shenyang Military Area Command of Chinese PLA, Liaoning, Shenyang
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语种
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英文 |
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文献类型
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研究性论文 |
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ISSN
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1673-5374 |
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学科
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基础医学;药学 |
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基金
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supported by the China Postdoctoral Science Foundation
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文献收藏号
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CSCD:5325093
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39
共2页
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