Synthesis and Biological Evaluation of Novel 5,7-Diphenylimidazo[1,2-a]pyridine Derivatives
查看参考文献17篇
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文摘
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A series of novel 5,7-diphenylimidazo[1,2-a]pyridine derivatives was designed and synthesized. The in vitro cytotoxic activities of all the target compounds against human colorectal cancer (HT-29), human lung can-cer (H460), human gastric cancer (MKN45) and human breast cancer (MDA-MB-231) cell lines were evaluated. The pharmacological results indicated that most of the target compounds showed moderate to excellent activities against the tested cell lines. The most promising compound 4h (0.20, 0.006, 0.08, 0.021 μmol/L) was 2.6, 5.1, 3.6 and 21.9 times more active than EPC2407 (0.52, 0.031, 0.29, 0.46 μmol/L) against HT-29, H460, MKN45 and MDA-MB-231 cell lines, respectively. |
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来源
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Chemical Research in Chinese Universities
,2014,30(5):759-763 【核心库】
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DOI
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10.1007/s40242-014-4081-3
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关键词
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Imidazo[1,2-a]pyridine
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Biological evaluation
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Antitumor activity
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地址
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Shenyang Pharmaceutical University, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang, 110016
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语种
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英文 |
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文献类型
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研究性论文 |
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ISSN
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1005-9040 |
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学科
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化学 |
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基金
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国家自然科学基金
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文献收藏号
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CSCD:5259969
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