基于体素的形态测量学方法分析视神经脊髓炎患者的灰质体积变化
A Voxel-based Morphometry Study of Grey Matter Volume Changes in Neuromyelitis Optica Patients
查看参考文献18篇
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文摘
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目的应用基于体素的形态测量学方法比较视神经脊髓炎患者与正常人的脑灰质体积,探讨视神经脊髓炎患者的脑灰质体积变化。方法入组16例视神经脊髓炎患者及16名性别、年龄匹配的健康志愿者,分别行全脑三维结构成像,应用基于统计参数图8软件的基于体素的形态测量学8 Toolbox工具箱分析视神经脊髓炎组及对照组的数据,比较两组脑灰质体积。结果与对照组相比,视神经脊髓炎组额叶、顶叶、颞叶、枕叶、边缘叶、视束、尾状核、丘脑、小脑的多个区域灰质体积减小(P均<0.005)。结论视神经脊髓炎患者局部脑区灰质萎缩,基于体素的形态测量学技术可以灵敏的反应脑体积变化。 |
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其他语种文摘
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Objective To explore the grey matter volume (GMV) changes in neuromyelitis optica (NMO) patients using a voxel-based morphometry method.Methods Whole brain structural images were acquired in 16 NMO patients and 16 gender-and age-matched healthy controls.Comparison of GMV between the two groups was analyzed by VBM8 toolbox of statistical parametric mapping 8.Result Compared with the controls, NMO patients showed decreased GMV in the frontal lobe,parietal lobe,temporal lobe,occipital lobe,limbic lobe,optic tract,caudate nucleus,thalamus,and cerebellum (all P < 0.005). Conclusions Regional atrophy of grey matter is found in NMO patients.Voxel-based morphometry can reveal brain volume changes sensitively. |
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来源
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中国医学科学院学报
,2014,36(4):432-438 【核心库】
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DOI
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10.3881/j.issn.1000-503x.2014.04.015
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关键词
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视神经脊髓炎
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磁共振成像
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基于体素的形态测量学
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灰质
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地址
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中国医学科学院北京协和医学院北京协和医院放射科, 北京, 100730
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中国医学科学院北京协和医学院北京协和医院神经科, 北京, 100730
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语种
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中文 |
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文献类型
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研究性论文 |
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ISSN
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1000-503X |
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学科
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临床医学 |
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基金
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国家自然科学基金
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文献收藏号
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CSCD:5231913
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