Synthesis and Tumor Cytotoxicity of Novel N-Substituted Glucosamine-bearing Oleanolic Acid Derivatives
查看参考文献17篇
|
文摘
|
Eleven novel triterpenoid saponins, N-substituted-?-D-glucosaminide derivatives of oleanolic acid, were designed and synthesized via a stepwise glycosylation strategy. These compounds were evaluated for in vitro cytotoxic activity against six different tumor cell lines. Most of the compounds inhibited the growth of, at least, one tumor cell line effectively at micromolar concentrations. Preliminary structure-activity relationships(SARs) indicate that acylation of the nitrogen of the glucosamine-bearing triterpenoid saponins affords the compounds that are highly cytotoxic towards specific tumor cell lines. |
|
来源
|
Chemical Research in Chinese Universities
,2014,30(4):639-643 【核心库】
|
|
DOI
|
10.1007/s40242-014-3522-3
|
|
关键词
|
N-Substituted glucosamine-bearing triterpenoid saponin
;
Tumor cytotoxicity
;
Oleanolic acid
|
|
地址
|
Shenyang Pharmaceutical University, Key Laboratory of Structure-based Drug Design and Discovery, Ministry of Education, Shenyang, 110016
|
|
语种
|
英文 |
|
文献类型
|
研究性论文 |
|
ISSN
|
1005-9040 |
|
学科
|
化学 |
|
基金
|
国家自然科学基金
;
the PhD Scientific Research Opening Foundation Projects of Liaoning Province of China
|
|
文献收藏号
|
CSCD:5214902
|
参考文献 共
17
共1页
|
|
1.
Parente J P.
Nat. Prod. Commun,2009,4(1):143
|
CSCD被引
2
次
|
|
|
|
|
2.
Luo J.
Bioorg. Med. Chem,2008,16(6):2912
|
CSCD被引
2
次
|
|
|
|
|
3.
Lanzotti V.
Phytochemistry Reviews,2005,4(2/3):95
|
CSCD被引
5
次
|
|
|
|
|
4.
Liang H.
Bioorg. Med. Chem. Lett,2005,15(20):4493
|
CSCD被引
2
次
|
|
|
|
|
5.
Zou K J.
Chin. J. Org. Chem,2005,25(6):654
|
CSCD被引
1
次
|
|
|
|
|
6.
Krief S.
J. Nat. Prod,2005,68(6):897
|
CSCD被引
2
次
|
|
|
|
|
7.
Zou K.
Carbohydr. Res,2005,340(7):1329
|
CSCD被引
9
次
|
|
|
|
|
8.
Abdel-Kader M.
J. Nat. Prod,2001,64(4):536
|
CSCD被引
6
次
|
|
|
|
|
9.
Seo Y.
J. Nat. Prod,2002,65(2):170
|
CSCD被引
3
次
|
|
|
|
|
10.
Wang B.
Bioorg. Med. Chem. Lett,2012,22(23):7110
|
CSCD被引
2
次
|
|
|
|
|
11.
Cheng M S.
Carbohydr. Res,2006,341(1):60
|
CSCD被引
5
次
|
|
|
|
|
12.
Yan M C.
Bioorg. Med. Chem. Lett,2006,16(16):4200
|
CSCD被引
5
次
|
|
|
|
|
13.
Yan M C.
Carbohydr. Res,2008,343(4):780
|
CSCD被引
3
次
|
|
|
|
|
14.
Liu Y.
Molecules,2010,15(11):7871
|
CSCD被引
1
次
|
|
|
|
|
15.
Seiichi I.
Tetrahedron Lett,2001,42(43):7613
|
CSCD被引
1
次
|
|
|
|
|
16.
Kaskiwa M J.
Bioorg. Med. Chem,2009,17(22):7670
|
CSCD被引
1
次
|
|
|
|
|
17.
Kaskiw M J.
Bioorg. Med. Chem,2008,16(6):3209
|
CSCD被引
4
次
|
|
|
|
|
了解气象卫星更多信息，请访问