Synthesis and Antitumor Activities of Novel 4-Morpholinothieno[3,2-d]pyrimidine Derivatives
查看参考文献13篇
|
文摘
|
A series of novel 2-hydrazinyl-4-morpholinothieno[3,2-d]pyrimidine derivatives was designed and synthesized. All of them were screened for their cytotoxic activities against large cell lung cancer(H460), colon cancer (HT-29) and adenocarcinomic lung cancer(A549) cell lines in vitro. The pharmacological results indicate that most of the target compounds show moderate to significant activities. Especially compound 17 exhibits the most potent antitumor activities against H460, HT-29 and A549 cell lines with IC_(50) values of 0.57, 0.45 and 1.45 μmol/L, respectively. |
|
来源
|
Chemical Research in Chinese Universities
,2014,30(1):75-81 【核心库】
|
|
DOI
|
10.1007/s40242-013-3281-6
|
|
关键词
|
2-Hydrazinyl-4-morpholinothieno[3,2-d]pyrimidine
;
Antitumor activity
;
Cytotoxic activity
|
|
地址
|
Shenyang Pharmaceutical University, Key Laboratory of Structure-based Drug Design and Discovery, Ministry of Education, Shenyang, 110016
|
|
语种
|
英文 |
|
文献类型
|
研究性论文 |
|
ISSN
|
1005-9040 |
|
学科
|
化学 |
|
基金
|
Supported by the 2010 Program for Innovative Research Team of the Ministry of Education of China
;
the Program for Liaoning Innovative Research Team in University, China
|
|
文献收藏号
|
CSCD:5051263
|
参考文献 共
13
共1页
|
|
1.
.
(WHO Media Centre Cancer,2013
|
CSCD被引
1
次
|
|
|
|
|
2.
Vivanco I.
Nat. Rev. Cancer,2002,2:489
|
CSCD被引
185
次
|
|
|
|
|
3.
Schuurbiers O C J.
J. Thorac. Oncol,2009,4:761
|
CSCD被引
9
次
|
|
|
|
|
4.
Dituri F.
Int. J. Cancer,2012,130:2505
|
CSCD被引
2
次
|
|
|
|
|
5.
Folkes A J.
J. Med. Chem,2008,51:5522
|
CSCD被引
18
次
|
|
|
|
|
6.
Sutherlin D P.
J. Med. Chem,2010,53:1087
|
CSCD被引
1
次
|
|
|
|
|
7.
Sutherlin D P.
J. Med. Chem,2011,54:7579
|
CSCD被引
6
次
|
|
|
|
|
8.
Zhu W F. Synthesis and cytotoxic activity of novel 2,6-disubstituted-4-morpholinothieno[3,2-d]pyrimidines as potent anti-tumor agents.
Chin. Chem. Lett,2012,23:703
|
CSCD被引
5
次
|
|
|
|
|
9.
Bravo-Altamirano K.
ACS Med. Chem. Lett,2011,2:154
|
CSCD被引
4
次
|
|
|
|
|
10.
Babu S.
Process for Making Thienopyrimidine Compounds, US8431694,2013
|
CSCD被引
1
次
|
|
|
|
|
11.
Wallace D M.
J. Org. Chem,1993,58:7245
|
CSCD被引
6
次
|
|
|
|
|
12.
Drost K J.
J. Org. Chem,1991,56:2240
|
CSCD被引
1
次
|
|
|
|
|
13.
Pavia M R.
J. Org. Chem,1990,55:560
|
CSCD被引
2
次
|
|
|
|
|
了解气象卫星更多信息，请访问