The prognostic role of PRUNE2 in leiomyosarcoma
查看参考文献13篇
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文摘
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PRUNE2 plays an important role in regulating tumor cell differentiation, proliferation, and invasiveness in neuroblastoma. Our previous study revealed that PRUNE2/OBSCN two-gene relative expression classifer accurately differentiated leiomyosarcoma from gastrointestinal stromal tumor. However, the association between PRUNE2 expression and prognosis in leiomyosarcoma is poorly understood. In this study, we evaluated the prognostic role of PRUNE2 in leiomyosarcoma. PRUNE2 expression was detected using immunohistochemistry in 30 formalin-fixed, paraffin-embedded leiomyosarcoma tissues from MD Anderson Cancer Center, and high expression was detected in 36.7% (11/30) of the samples. To validate these results, immunohistochemistry was performed on another cohort of 45 formalin-fixed, paraffin-embedded leiomyosarcoma tissues from Tianjin Medical University Cancer Institute & Hospital, and high PRUNE2 protein expression was detected in 37.8% (17/45) of the samples. Moreover, elevated PRUNE2 expression was significantly associated with tumor size (P = 0.03) and hemorrhage/cyst (P = 0.014), and was an independent favorable prognostic factor for overall survival in leiomyosarcoma patients from Tianjin Medical University Cancer Institute & Hospital (P < 0.05). These data suggest that increased PRUNE2 protein expression may serve as a favorable prognostic marker in human leiomyosarcoma. |
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来源
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Chinese Journal of Cancer
,2013,32(12):648-652 【核心库】
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关键词
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Leiomyosarcoma
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PRUNE2
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survival
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prognosis
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地址
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1.
Department of Bone and Soft Tissue Tumor, Tianjin Medical University Cancer Hospital & Institute, Tianjin, 300060
2.
Epidemiology and Biostatistics, Tianjin Medical University Cancer Hospital & Institute, Tianjin, 300060
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语种
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英文 |
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文献类型
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研究性论文 |
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ISSN
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1000-467X |
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学科
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肿瘤学 |
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基金
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supported by grants from the National Nature Science Foundation of China to J. Yang
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supported by grants from the National Nature Science Foundation of China to K. Chen
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the University Cancer Foundation via the Sister Institution Network Fund (SINF) at the Tianjin Medical University Cancer Institute & Hospital (TMUCIH)
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Fudan University Shanghai Cancer Center (FUSCC)
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University of Texas MD Anderson Cancer Center (UTMDACC)
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Changjiang Scholars and Innovative Research Team in University (PCSIRT) in China
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National Key Scientific and Technological Project (K. Chen)
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文献收藏号
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CSCD:5007773
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