Synthesis and biological evaluation of new pyrrolopyrazinone compounds as potential antitumor agents

Meng Ying ¹ Wang Guan ² Li Yue ¹ Hou Kuan ¹ Yuan Yue ¹ Zhang Lijuan ¹ Song Hongrui ¹ ^* Shi Wei ² ^*

文摘	A series of pyrrolo[1,2-a]pyrazinone compounds(5a-9f) were synthesized,and their cytotoxic activity against SKOV-3,A549.HeLa cells in vitro were evaluated by the MTT method.Some of the compounds showed potential antitumor activity against three tumor cell lines.Among them,compounds 9c and 9d showed the most potent cytotoxic activity.The preliminary mechanism of action was discussed
来源	Chinese Chemical Letters ,2013,24(7):619-621 【核心库】
DOI	10.1016/j.cclet.2013.04.020
关键词	Pyrrolopyrazinone ; Antitumor ; Synthesis
地址	1. Shenyang Pharmaceutical University, Key Laboratory of Structure-Based Drug Design and Discovery,Ministry of Education, Shenyang, 110016 2. Jilin University, Key Laboratory for Molecular Enzymology and Engineering,Ministry of Education, Changchun, 130012
语种	英文
文献类型	研究性论文
ISSN	1001-8417
学科	化学工业
文献收藏号	CSCD:4904853

参考文献共 6 共1页

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引证文献 1 篇

1 Meng Ying Design, Synthesis and Antitumor Activity of Pyrrolopyrazinone-chalcone Hybrids Chemical Research in Chinese Universities,2014,30(4):624-631
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