CRF受体对五羟色胺系统的调节作用及早期环境因素的影响
The Roles of CRF Receptors in the Modulation of Serotoninergic System and the Effects of Early Environmental Factors
查看参考文献61篇
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文摘
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早期环境因素持续影响脑与行为的发展,增加个体成年后应激相关精神疾病患病的易感性。应激反应的中枢启动因子促肾上腺皮质激素释放因子(corticotropin-releasing factor,CRF)通过两种受体CRF1和CRF2调节中缝背核(dorsal raphe nucleus,DRN)-五羟色胺(serotonin,5-HT)系统,后者已被证实在应激相关情绪疾患发病和治疗过程中发挥重要作用。已知CRF受体以相互影响相互拮抗的方式动态调节DRN-5-HT系统,提示这两种受体相对作用的调节对于协调复杂环境中DRN-5-HT系统的应激反应过程起着关键性作用。早期环境因素和遗传因素交互作用导致CRF受体的分布和反应性持续改变并造成DRN-5-HT系统反应异常,可能是导致应激反应和精神疾病易感性个体差异的重要神经基础。 |
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其他语种文摘
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Early environmental factors had long-term effects on the development of brain and behaviors, and led to a variety of psychopathological changes. It is well known that the dorsal raphe nucleus (DRN)-serotonin (5-HT) system is implicated in the onset and treatment of stress-related psychiatric disorders. Corticotropin-releasing factor (CRF) modulates activity of this system during stress via activation of two receptors: CRF1 and CRF2. CRF1 and CRF2 mediated inhibition and excitation of the DRN-5-HT system respectively. Therefore, the regulation of the relative contribution of the two CRF receptors to brain CRF pathways may be essential in coordinating 5-HTergic responses to stress. The early environmental factors (e.g. stress) induced long-term even lifetime changes in the distribution and reactivity of CRF receptors, and the DRN-5-HT system response to further stressful stimuli, which might be involved in the individual differences of susceptibility to stress-related psychiatric disorders |
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来源
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心理科学进展
,2013,21(6):982-989 【核心库】
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关键词
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促肾上腺皮质激素释放激素
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早期环境因素
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中缝背核
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五羟色胺
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地址
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1.
中国科学院心理研究所, 中国科学院心理健康重点实验室, 北京, 100101
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北京大学心理学系, 北京, 100871
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语种
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中文 |
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文献类型
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研究性论文 |
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ISSN
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1671-3710 |
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学科
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社会科学总论 |
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基金
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国家自然科学基金项目
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中国科学院知识创新工程项目
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中国科学院心理健康重点实验室、中国科学院心理研究所资助
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文献收藏号
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CSCD:4861690
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