Brain cell apoptosis and enhancement of nervous excitability in pregnant rats with high plasma levels of homocysteine
查看参考文献21篇
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文摘
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Hyperhomocysteinemia is an important risk factor for preeclampsia-eclampsia. This study established a pregnant rat model of hyperhomocysteinemia, in which blood plasma homocysteine concentrations were twice or three times greater than that of normal pregnant rats. TUNEL revealed an increase in the number of apoptotic cells in the frontal cortex of pregnant rats with hyperhomocysteinemia. In addition, immunohistochemical staining detected activated nuclear factor-κB-positve cells in the frontal cortex. Reverse transcription-PCR detected that mRNA expression of the anti-apoptotic gene bcl-2 diminished in the frontal cortex. In situ hybridization and western blotting revealed that N-methyl-D- aspartate receptor 1 mRNA and protein expression was upregulated in the frontal cortex and hippocampus. These results indicate that hyperhomocysteinemia can induce brain cell apoptosis, increase nerve excitability, and promote the occurrence of preeclampsia in pregnant rats. |
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来源
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Neural Regeneration Research
,2012,7(28):2199-2205 【核心库】
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DOI
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10.3969/j.issn.1673-5374.2012.028.005
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关键词
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hyperhomocysteinemia
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homocysteine
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preeclampsia
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frontal cortex
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N-methyl-D-aspartate receptor
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nerve excitability
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cell apoptosis
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pregnancy
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brain
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neural regeneration
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地址
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1.
Department of Gynaecology and Obstetrics, General Hospital of Shenyang Military Region, Liaoning, Shenyang, 110016
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Department of Gynaecology and Obstetrics, the 202 Hospital of Chinese PLA, Liaoning, Shenyang, 110003
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Shenyang Women and Children Health Center, Liaoning, Shenyang, 110014
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语种
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英文 |
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ISSN
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1673-5374 |
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学科
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妇产科学 |
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基金
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funded by the General Project of Medical Technology of Military during the "12th Five-Year Plan" Period
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文献收藏号
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CSCD:4664136
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参考文献 共
21
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