建立基于个体生理监护信息的呼吸力学模型
Mathematic model of respiratory mechanics based on monitored physiological parameters
查看参考文献17篇
|
文摘
|
目的建立考虑气血交换的呼吸力学理论模型,将机械通气时血液中的气体含量与呼吸系统的力学规律联系起来。方法考虑循环系统与呼吸过程生理参数的耦合,将常规的临床监护参数(如血液中O2和CO2的气体含量、血红蛋白含量、心率和心输出量等)与肺泡内气体分子数相联系,进而建立力学模型得到气道与肺泡不同时刻的气体含量、压力和流量等动力学参量。结果利用模型估算了呼吸系统不同部位的气体含量,并分析了呼出气体含量对各个待定参数的敏感性。结论本文所发展的呼吸力学模型对利用临床生理监护参数调控机械通气做了初步的尝试,随着后续实验工作的开展将有可能为新型呼吸机的设计和研发提供理论支持。 |
|
其他语种文摘
|
Objective To establish a model of respiratory mechanics with consideration of gas exchange and directly correlate with the gas content in blood during mechanical ventilation with the mechanics of respiratory system.Methods By coupling the physiological parameters of respiratory system and blood circulation system,including the molecular numbers of oxygen and carbon dioxide in alveoli and clinically monitored physiological parameters such as gas content,hemoglobin content,heart rate and cardiac output,a mechanical model was constructed to predict those dynamic parameters of gas content,pressure and flow rate in airway and alveoli in continuous breathing cycles.Results The gas content in different locations of a respiratory system was estimated by the model and the sensitivity of gas content in expiration to the undetermined parameters was evaluated.Conclusions The model of respiratory mechanics developed in the study is a preliminary attempt to predict the regulation roles of physiological parameters clinically monitored during mechanical ventilation,which will provide a theoretical support for the design and development of novel respirators in the follow-up experiment. |
|
来源
|
医用生物力学
,2012,27(4):409-415 【扩展库】
|
|
关键词
|
呼吸力学
;
气血交换
;
机械通气
;
呼吸机
;
生理监护参数
|
|
地址
|
1.
中国科学院力学研究所生物力学与生物工程中心, 北京, 100190
2.
航天长峰股份有限公司, 北京, 100071
|
|
语种
|
中文 |
|
ISSN
|
1004-7220 |
|
学科
|
基础医学 |
|
基金
|
科技部国家高技术研究发展计划(863计划)资助项目
;
国家自然科学基金
|
|
文献收藏号
|
CSCD:4625912
|
参考文献 共
17
共1页
|
|
1.
Rahn H. The pressure-volume diagram of the thorax and lung.
Fed Proc,1946,5(1 Pt 2):82
|
CSCD被引
1
次
|
|
|
|
|
2.
Pereira C. Sigmoidal equation for lung and chest wall volume-pressure curves in acute respiratory failure.
J Appl Physiol,2003,95(5):2064-2071
|
CSCD被引
3
次
|
|
|
|
|
3.
Antonaglia V. Gas distribution in a two-compartment model during volume or pressure ventilation: Role of elastic elements.
Resp Physiol Neurobiol,2010,171(3):225-231
|
CSCD被引
2
次
|
|
|
|
|
4.
Aboab J. Relation between PaO_2 /FIO_2 ratio and FIO_2: A mathematical description.
Intens Care Med,2006,32(10):1494-1497
|
CSCD被引
6
次
|
|
|
|
|
5.
孙栋. 人体上呼吸道中气流涡结构特征数值仿真研究.
医用生物力学,2011,26(3):262-268
|
CSCD被引
10
次
|
|
|
|
|
6.
Dominguez de Villota E D. Equality of the in vivo and in vitro oxygen-binding capacity of haemoglobin in patients with severe respiratory disease.
Brit J Anaesth,1981,53(12):1325-1328
|
CSCD被引
2
次
|
|
|
|
|
7.
Wilson A J. A computer model of the artificially ventilated human respiratory system in adult intensive care.
Med Eng Phys,2009,31(9):1118-1133
|
CSCD被引
2
次
|
|
|
|
|
8.
易韦韦. 基于主动模拟肺通气模式试验平台的设计与实现.
电子测量与仪器学报,2009,23(5):92-96
|
CSCD被引
4
次
|
|
|
|
|
9.
Schirrmann K. Theoretical modeling of the interaction between alveoli during inflation and deflation in normal and diseased lungs.
J Biomech,2010,43(6):1202-1207
|
CSCD被引
3
次
|
|
|
|
|
10.
Duranti R. Respiratory mechanics in patients with tense cirrhotic ascites.
Eur Respir J,1997,10(7):1622-1630
|
CSCD被引
1
次
|
|
|
|
|
11.
Reynolds A. A mathematical model of pulmonary gas exchange under inflammatory stress.
J Theor Biol,2010,264(2):161-173
|
CSCD被引
3
次
|
|
|
|
|
12.
Ladakis C. Central venous and mixed venous oxygen saturation in critically ill patients.
Respiration,2001,68(3):279-285
|
CSCD被引
8
次
|
|
|
|
|
13.
Niklason L. The influence of venous admixture on alveolar dead space and carbon dioxide exchange in acute respiratory distress syndrome: computer modelling.
Critical Care,2008,12(2):R53
|
CSCD被引
5
次
|
|
|
|
|
14.
Chawla L S. Lack of equivalence between central and mixed venous oxygen saturation.
Chest,2004,126(6):1891-1896
|
CSCD被引
4
次
|
|
|
|
|
15.
舒伟锋. 混合静脉血氧饱和度监测及其在临床上的应用.
浙江医学,2008,30(2):194-196
|
CSCD被引
2
次
|
|
|
|
|
16.
el-Masry A. Comparison of central venous oxygen saturation and mixed venous oxygen saturation during liver transplantation.
Anaesthesia,2009,64(4):378-382
|
CSCD被引
3
次
|
|
|
|
|
17.
Opitz C F. Assessment of the vasodilator response in primary pulmonary hypertension. Comparing prostacyclin and iloprost administered by either infusion or inhalation.
Euro Heart J,2003,24(4):356-365
|
CSCD被引
11
次
|
|
|
|
|
了解气象卫星更多信息，请访问