Brain functional changes in facial expression recognition in patients with major depressive disorder before and after antidepressant treatment A functional magnetic resonance imaging study
查看参考文献38篇
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文摘
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Functional magnetic resonance imaging was used during emotion recognition to identify changes in functional brain activation in 21 first-episode, treatment-naive major depressive disorder patients before and after antidepressant treatment. Following escitalopram oxalate treatment, patients exhibited decreased activation in bilateral precentral gyrus, bilateral middle frontal gyrus, left middle temporal gyrus, bilateral postcentral gyrus, left cingulate and right parahippocampal gyrus, and increased activation in right superior frontal gyrus, bilateral superior parietal lobule and left occipital gyrus during sad facial expression recognition. After antidepressant treatment, patients also exhibited decreased activation in the bilateral middle frontal gyrus, bilateral cingulate and right parahippocampal gyrus, and increased activation in the right inferior frontal gyrus, left fusiform gyrus and right precuneus during happy facial expression recognition. Our experimenta findings indicate that the limbic-cortical network might be a key target region for antidepressant treatment in major depressive disorder. |
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来源
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Neural Regeneration Research
,2012,7(15):1151-1157 【核心库】
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DOI
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10.3969/j.issn.1673-5374.2012.15.005
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关键词
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major depressive disorder
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functional magnetic resonance imaging
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facial expression recognition
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antidepressant
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neural regeneration
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地址
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1.
Department of Psychiatry, the First Affiliated Hospital, China Medical University, Liaoning, Shenyang, 110001
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Department of Neurosurgery, PLA 463 Hospital, Liaoning, Shenyang, 110042
3.
Department of Radiology, the First Affiliated Hospital, China Medical University, Liaoning, Shenyang, 110001
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语种
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英文 |
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文献类型
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研究性论文 |
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ISSN
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1673-5374 |
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学科
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临床医学 |
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基金
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国家自然科学基金
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Liaoning Science and Technology Foundation
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Doctoral Foundation of the First Affiliated Hospital in China Medical University
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文献收藏号
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CSCD:4571280
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38
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