高唤醒对创伤后应激障碍形成发展的影响及其神经机制
The Neural Mechanism Underlying Hyperarousal and Its Role in the Development of Posttraumatic Stress Disorder
查看参考文献49篇
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文摘
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高唤醒是创伤后应激障碍(PTSD)的主要症状之一,对创伤后应激障碍的形成与发展起核心作用。急性应激期产生的高唤醒可以预测其后PTSD的回避与麻木、再体验等症状的形成,在创伤后早期,降低唤醒程度可以减轻PTSD相关的症状表现。下丘脑-垂体-肾上腺轴异常变化会导致去甲肾上腺素(NE)、促肾上腺皮质激素释放因子(CRF)过度释放,同时皮质醇(酮)水平下降,这二者是高唤醒产生与维持的主要原因。另外,5-羟色胺(5-HT)系统的高度激活也影响了高唤醒的形成。食欲素神经肽与NE、CRF与5-HT系统有密切的神经联系,可能参与高唤醒的调节,是近年来研究的一个热点。 |
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其他语种文摘
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Hyperarousal represents the core symptoms of posttraumatic stress disorder (PTSD) and plays a significant role in the development of PTSD. Peri-traumatic hyperarousal response predicts the occurrence of the PTSD symptoms like re-experience, avoidance and numbing, and attenuating the magnitude of the arousal response during peri-traumatic period can reduce the risk to develop PTSD symptom. Dysfunction of hypothalamic–pituitary–adrenal axis characterized with over-release of norepinephrine (NE) and corticotropin-releasing factor (CRF), but lack of cortisol or corticosterone is one of the most important neural mechanisms which cause and maintain the long-term hyperarousal state. Over-activation of serotonin (5-HT) system is also related to the hyperarousal situation after the traumatic experience. Recently, the role of orexin system in hypothalamus in hyperaroual or stress has attracted a lot of attention, because the orexin system is closely connected with NE, CRF and 5-HT system and it is vital in sleep and arousal transition. |
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来源
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心理科学进展
,2011,19(11):1651-1657 【核心库】
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关键词
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创伤后应激障碍
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高唤醒
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食欲素
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地址
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1.
中国科学院心理研究所, 中国科学院心理健康院重点实验室, 北京, 100101
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山东省潍坊市益都中心医院, 潍坊, 262500
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语种
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中文 |
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文献类型
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研究性论文 |
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ISSN
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1671-3710 |
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学科
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社会科学总论;基础医学 |
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基金
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国家自然科学基金
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中国科学院知识创新工程项目
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文献收藏号
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CSCD:4380081
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