安慰剂镇痛及内在机制
Placebo analgesia and its underlying mechanisms
查看参考文献23篇
|
文摘
|
安慰剂镇痛效应在常规临床实践中有着非常重要的作用和意义。有意识的预期过程及无意识的条件反射均能产生安慰剂镇痛效应，并影响相应的生理功能。安慰剂镇痛效应可以分为阿片和非阿片成分，这两类安慰剂镇痛效应可能涉及不同的通道、脑区及相关大脑回路。本文综述了产生安慰剂镇痛的机制及神经生理学研究进展，并提出今后的研究方向。 |
|
其他语种文摘
|
Placebo effect is a biological phenomenon with psychosocial-induced biochemical changes in a patient's brain and body. The term placebo-related effects aims to extend the concept of placebo effect to related phenomena and makes the underlying mechanisms better understood. The placebo analgesia effect is induced by different mechanisms, including the expectation of pain relief and conditioning. According to pharmacological studies, placebo analgesia is subdivided into opioid and non-opioid components while functional imaging data has also revealed brain regions and brain network involved in placebo analgesia. On the basis of previous research, this paper discussed the definition and underlying mechanisms of placebo analgesia, and gave some suggestions about related study in future. |
|
来源
|
中国临床药理学与治疗学
,2011,16(10):1197-1200 【核心库】
|
|
关键词
|
安慰剂
;
镇痛
;
条件化
;
期待
;
机制
|
|
地址
|
中国科学院心理研究所, 中国科学院心理健康院重点实验室, 北京, 100101
|
|
语种
|
中文 |
|
文献类型
|
综述型 |
|
ISSN
|
1009-2501 |
|
学科
|
药学 |
|
基金
|
国家自然科学基金资助
|
|
文献收藏号
|
CSCD:4373441
|
参考文献 共
23
共2页
|
|
1.
杜宝俊. 中药新药临床研究方案设计中相关问题探讨.
中国临床药理学与治疗学,2005,10(9):1073-1075
|
CSCD被引
3
次
|
|
|
|
|
2.
马玉全. 非劣效试验中对照的选择和界值确定方法.
中国临床药理学与治疗学,2009,14(9):961-965
|
CSCD被引
4
次
|
|
|
|
|
3.
Beecher H K. The powerful placebo.
JAMA,1955,159(17):1602-1606
|
CSCD被引
20
次
|
|
|
|
|
4.
Levine J D. Analgesic responses to morphine and placebo in individuals with postoperative pain.
Pain,1981,10(3):379-389
|
CSCD被引
2
次
|
|
|
|
|
5.
Thompson W G. Placebos: a review of the placebo response.
Am J Gastroenterology,2000,95(7):1637-1643
|
CSCD被引
1
次
|
|
|
|
|
6.
Benedetti F. Mechanisms of placebo and placebo-related effects across diseases and treatments.
Annu Rev Pharmacol Toxicol,2008,48(1):33-60
|
CSCD被引
4
次
|
|
|
|
|
7.
White L.
A conditioned response model of the placebo effect: predictions of the model,1985:255-287
|
CSCD被引
1
次
|
|
|
|
|
8.
Amanzio M. Neuropharmacological dissection of placebo analgesia: expectation-activated opioid systems versus conditioning-activated specific subsystems.
J Neurosci,1999,19(1):484-494
|
CSCD被引
6
次
|
|
|
|
|
9.
Gracely R H. Clinicians' expectations influence placebo analgesia.
Lancet,1985,1(8419):43
|
CSCD被引
4
次
|
|
|
|
|
10.
Levine J D. The mechanism of placebo analgesia.
Lancet,1978,2(6):654-657
|
CSCD被引
13
次
|
|
|
|
|
11.
Guo J Y. Dissection of placebo analgesia in mice: the conditions for activation of opioid and non-opioid systems.
J Psychopharmcol,2010,24(10):1561-1567
|
CSCD被引
5
次
|
|
|
|
|
12.
Benedetti F. Potentiation of placebo analgesia by proglumide.
Lancet,1995,346(13):1321
|
CSCD被引
1
次
|
|
|
|
|
13.
Benedetti F. Disruption of opioid-induced placebo responses by activation of cholecystokinin type-2 receptors.
Psychopharmcol,2011,213(8):791-797
|
CSCD被引
1
次
|
|
|
|
|
14.
Benedetti F. Opioid-mediated placebo responses boost pain endurance and physical performance: is it doping in sport competitions.
J Neurosci,2007,27(44):11934-11939
|
CSCD被引
2
次
|
|
|
|
|
15.
Scott D J. Individual differences in reward responding explain placeboinduced expectations and effects.
Neuron,2007,55(2):325-336
|
CSCD被引
9
次
|
|
|
|
|
16.
Wager T D. Placeboinduced changes in FMRI in the anticipation and experience of pain.
Science,2004,303(5661):1162-1164
|
CSCD被引
32
次
|
|
|
|
|
17.
Bingel U. Mechanisms of placebo analgesia: rACC recruitment of a subcortical antinociceptive network.
Pain,2006,120(1/2):8-15
|
CSCD被引
10
次
|
|
|
|
|
18.
Petrovic P. A prefrontal non-opioid mechanism in placebo analgesia.
Pain,2010,150(1):59-65
|
CSCD被引
5
次
|
|
|
|
|
19.
Watson A. Place bo conditioning and placebo analgesia modulate a common brain network during pain anticipation and perception.
J Midwifery Worn Heal,2009,145(1):24-30
|
CSCD被引
1
次
|
|
|
|
|
20.
Lui F. Neural bases of conditioned placebo analgesia.
Pain,2010,151(3):816-824
|
CSCD被引
3
次
|
|
|
|
|
了解气象卫星更多信息，请访问