Synergism of irbesartan and amlodipine on hemodynamic amelioration and organ protection in spontaneously hypertensive rats
查看参考文献37篇
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文摘
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Aim: To investigate the synergism of low-doses of amlodipine and irbesartan on reduction of blood pressure variability (BPV), amelioration of baroreflex sensitivity (BRS) and organ protection in spontaneously hypertensive rats (SHR). Methods: The rats were administered amlodipine (1 mg·kg-1·d-1) alone, irbesartan (10 mg·kg-1d-') alone, or the combination of the two drugs for 4 months. The drugs were mixed into the rat chow. Blood pressure (BP) was continuously monitored in conscious animals. After the determination of BRS, the rats were killed for morphological evaluation of organ damages. Results: The combination of low-dose irbesartan and amlodipine had statistically significant synergism on reduction of BP and BPV, amelioration of BRS and organ protection in SHR. Multiple regression analysis showed that the decrease in left ventricular hypertrophy was associated with the decrease in systolic BPV (r=0.665, P<0.01); the decrease in aortic hypertrophy was associated with the increase in BRS (r=0.656, P<0.01); and the amelioration in renal lesion was associated with the increase in BRS (r=0.763, P<0.01) and the decrease in systolic BPV (r=0.706, P<0.01). Conclusion: Long-term treatment with a combination of low-doses of amlodipine and irbesartan showed significant synergism on reduction of BP and BPV, restoration of BRS and organ protection in SHR. Besides BP reduction, the enhancement of BRS and reduction of BPV might contribute to the organ protection. |
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来源
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Acta Pharmacologica Sinica
,2011,32(9):1109-1115 【核心库】
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DOI
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10.1038/aps.2011.88
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关键词
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hypertension
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spontaneously hypertensive rats (SHR)
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amlodipine
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irbesartan
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hypertension
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end organ damage
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blood pressure variability
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baroreflex sensitivity
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地址
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1.
Department of Pharmacology, Second Military Medical University, Shanghai, 200433
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School of the Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang, 110016
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语种
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英文 |
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文献类型
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研究性论文 |
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ISSN
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1671-4083 |
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学科
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药学 |
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基金
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National Science and Tech-nology Major Project
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国家自然科学基金
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文献收藏号
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CSCD:4335557
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参考文献 共
37
共2页
|
|
1.
Kikuya M. Prognostic significance of blood pressure and heart rate variabilities: the Ohasama study.
Hypertension,2000,36:901-906
|
CSCD被引
16
次
|
|
|
|
|
2.
Parati G. Blood pressure variability as a risk factor.
Blood Press Monit,2001,6:341-347
|
CSCD被引
2
次
|
|
|
|
|
3.
Su DF. Reduction of blood pressure variability: a new strategy for the treatment of hypertension.
Trends Pharmacol Sci,2005,26:388-390
|
CSCD被引
14
次
|
|
|
|
|
4.
Su DF. Functional studies of arterial baroreflex function in conscious rats.
Acta Pharmacol Sin,2002,23:673-679
|
CSCD被引
5
次
|
|
|
|
|
5.
Sleight P. The importance of autonomic nervous system in health and disease.
Aust N ZJ Med,1997,27:467-473
|
CSCD被引
1
次
|
|
|
|
|
6.
Liu JG. Contribution of blood pressure variability to the effect of nitrendipine on end-organ damage in spontaneously hypertensive rats.
J Hypertens,2003,21:1961-1967
|
CSCD被引
7
次
|
|
|
|
|
7.
Gupta AK. Compliance, safety, and effectiveness of fixed-dose combinations of antihypertensive agents: a meta-analysis.
Hypertension,2010,55:399-407
|
CSCD被引
30
次
|
|
|
|
|
8.
Chobanian AV. Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure.
Hypertension,2003,42:1206-1252
|
CSCD被引
270
次
|
|
|
|
|
9.
Xie HH. Effects of long-term treatment with candesartan on organ damages in sinoaortic denervated rats.
J Cardiovasc Pharmacol,2003,41:325-331
|
CSCD被引
6
次
|
|
|
|
|
10.
Norman RA Jr. Continuous monitoring of arterial pressure indicates sinoaortic denervated rats are not hypertensive.
Hypertension,1981,3:119-125
|
CSCD被引
6
次
|
|
|
|
|
11.
Smyth HS. Reflex regulation of arterial pressure during sleep in man: a quantitative method of assessing baroreflex sensitivity.
Circ Res,1969,24:109-121
|
CSCD被引
24
次
|
|
|
|
|
12.
Su DF. Determination of arterial baroreflexblood pressure control in conscious rats.
Acta Pharmacol Sin,2002,23:103-109
|
CSCD被引
4
次
|
|
|
|
|
13.
Xie HH. Synergism of atenolol and nitrendipine on hemodynamic amelioration and organ protection in hypertensive rats.
J Hypertens,2005,23:193-201
|
CSCD被引
14
次
|
|
|
|
|
14.
Hayakawa H. The link among nitric oxide synthase activity, endothelial function, and aortic and ventricular hypertrophy in hypertension.
Hypertension,1997,29:235-241
|
CSCD被引
9
次
|
|
|
|
|
15.
Miao CY. Aterial remodeling in chronic sinoaortic-denervated rats.
J Cardiovasc Pharmacol,2001,37:6-15
|
CSCD被引
15
次
|
|
|
|
|
16.
Kimula K. Renel arteriolar diameters in spontaneously hypertensive rats: Vascular cast study.
Hypertension,1991,18:101-110
|
CSCD被引
3
次
|
|
|
|
|
17.
Jin ZJ. About the evaluation of drug combination.
Acta Pharmacol Sin,2004,25:146-147
|
CSCD被引
15
次
|
|
|
|
|
18.
Su DF. Two useful methods for evaluating antihypertensive drugs in conscious freely moving rats.
Acta Pharmacol Sin,2004,25:148-151
|
CSCD被引
4
次
|
|
|
|
|
19.
Waeber B. Amlodipine and valsartan as components of a rational and effective fixed-dose combination.
Vasc Health Risk Manag,2009,5:165-174
|
CSCD被引
3
次
|
|
|
|
|
20.
Luft FC. Calcium channel blockade with nitrendipine. Effects on sodium homeostasis, the renin-angiotensin system, and the sympathetic nervous system in humans.
Hypertension,1985,7:438-442
|
CSCD被引
3
次
|
|
|
|
|
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