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Changes in serum levels of soluble osteoclast-associated receptor in human rheumatoid arthritis
查看参考文献7篇
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文摘
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Background Osteoclast-associated receptor (OSCAR) is a member of the newly identified leukocyte receptor complex, and has recently been described as a key molecule in osteoclastogenesis. In this study, we measured the levels of soluble osteoclast-associated receptor (sOSCAR) in the serum of rheumatoid arthritis (RA) patients and healthy controls to examine whether sOSCAR may play a role in the process of inflammatory arthritis. Methods Enzyme-linked immunosorbent assay (ELISA) was used to measure the levels of sOSCAR in the serum of 40 healthy controls and 40 RA patients. Results The serum levels of sOSCAR were significantly lower in RA patients than in healthy controls, and were inversely associated with inflammatory activity. Conclusion sOSCAR is decreased in patients with RA and reduced levels of the protein are associated with increased inflammatory response. |
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来源
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Chinese Medical Journal
,2011,124(19):3058-3060 【核心库】
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DOI
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10.3760/cma.j.issn.0366-6999.2011.19.019
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关键词
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Osteoclast
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Osteoclast-associated receptor
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Rheumatoid arthritis
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地址
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Department of Rheumatism, Shengjing Hospital, China Medical University, Liaoning, Shenyang, 110004
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语种
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英文 |
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文献类型
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研究性论文 |
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ISSN
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0366-6999 |
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学科
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外科学 |
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基金
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国家自然科学基金
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文献收藏号
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CSCD:4321541
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