Association of tag SNPs of GPx-3 with essential hypertension in rural Han Chinese in Fuxin,Liaoning,China
查看参考文献23篇
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文摘
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Background Genetic mechanisms contribute to blood pressure regulation.This study investigated whether glutathione peroxidase (GPx-3)tag single nucleotide polymorphisms (SNPs)are associated with hypertension in the rural areas of Fuxin county,Liaoning province,China.Methods Indigenous Fuxin Han people participated,523 unrelated hypertensives and 547 controls were recruited.All tag SNPs of GPx-3 gene were selected.We estimated SNP allele frequency in DNA pools with pyrosequencing.Results Before Bonferroni correction,C allele frequency for rs8177417 was significantly higher in hypertensives than those in controls (23.4% vs.19.3%,P=0.014); T allele frequency for rs3828599 was significantly lower in hypertensives than those in controls (35.6% vs.40.8%,P=0.009).However,when a Bonferroni correction for multiple testing was applied,only the polymorphisms rs3828599 of GPx-3 gene was associated with hypertension (P=0.045,OR:0.833,95% Cl:0.695-0.998).Conclusion The polymorphism of rs3828599 of GPx-3 gene might be associated with hypertension in rural Han Chinese from Fuxin,Liaoning. |
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来源
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Chinese Medical Journal
,2011,124(14):2113-2116 【核心库】
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DOI
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10.3760/cma.j.issn.0366-6999.2011.14.006
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关键词
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hypertension
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Han Chinese
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GPx-3 gene
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association
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地址
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Department of Cardiology,First Hospital of China Medical University, Liaoning, Shenyang, 110001
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语种
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英文 |
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文献类型
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研究性论文 |
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ISSN
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0366-6999 |
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学科
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中国医学 |
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基金
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Special Program for Key Basic Research of the Ministry of Science and Technology,China
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文献收藏号
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CSCD:4319811
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参考文献 共
23
共2页
|
|
1.
Kearney PM. Global burden of hypertension:analysis of worldwide data.
Lancet,2005,365:217-223
|
CSCD被引
232
次
|
|
|
|
|
2.
Ji W. Rare independent mutations in renal salt handling genes contribute to blood pressure variation.
Nat Genet,2008,40:592-599
|
CSCD被引
23
次
|
|
|
|
|
3.
Katori M. The renal kallikrein-kinin system:its role as a safety valve for excess sodium intake,and its attenuation as a possible etiologic factor in salt-sensitive hypertension.
Crit Review Clin Lab Sci,2003,40:43-115
|
CSCD被引
3
次
|
|
|
|
|
4.
Wilcox CS. Reactive oxygen species:role in blood pressure and kidney function.
Curr Hypertens Rep,2002,4:160-166
|
CSCD被引
12
次
|
|
|
|
|
5.
Griendling KK. NAD(P)H oxidase:role in cardiovascular biology and disease.
Circ Res,2000,86:494-501
|
CSCD被引
67
次
|
|
|
|
|
6.
Kawada N. A mouse model of angiotensin II slow pressor response:role of oxidative stress.
J Am Soc Nephrol,2002,13:2860-2868
|
CSCD被引
5
次
|
|
|
|
|
7.
Barton M. Dysfunctional renal nitric oxide synthase as a determinant of salt-sensitive hypertension:mechanisms of renal artery endothelial dysfunction and role of endothelin for vascular hypertrophy and glomerulosclerosis.
J Am Soc Nephrol,2000,11:835-845
|
CSCD被引
2
次
|
|
|
|
|
8.
Meng S. Superoxide dismutase and oxidative stress in Dahl salt-sensitive and-resistant rats.
Am J Physiol Regul Integr Comp Physiol,2002,283:R732-R738
|
CSCD被引
4
次
|
|
|
|
|
9.
Lenda DM. Effect of a high-salt diet on oxidant enzyme activity in skeletal muscle microcirculation.
Am J Physiol Heart Circ Physiol,2002,282:H395-H402
|
CSCD被引
2
次
|
|
|
|
|
10.
Bierl C. Determinants of human plasma glutathione peroxidase(GPx-3)expression.
J Biol Chem,2004,279:26839-26845
|
CSCD被引
4
次
|
|
|
|
|
11.
Muzakova V. Selective antioxidant enzymes during ischemia/reperfusion in myocardial infarction.
Physiol Res,2000,49:315-322
|
CSCD被引
2
次
|
|
|
|
|
12.
Sun Z. The accelerating epidemic of hypertension among rural Chinese women:results from Liaoning Province.
Am J Hypertens,2008,21:784-788
|
CSCD被引
2
次
|
|
|
|
|
13.
Sun Z. Incidence and predictors of hypertension among rural Chinese adults.results from Liaoning province.
Ann Fam Med,2010,8:19-24
|
CSCD被引
12
次
|
|
|
|
|
14.
Gu D. InterASIA Collaborative Group.The International Collaborative Study of Cardiovascular Disease in ASIA.Prevalence,awareness,treatment,and control of hypertension in China.
Hypertension,2002,40:920-927
|
CSCD被引
63
次
|
|
|
|
|
15.
Lavebratt C. Single nucleotide polymorphism(SNP)allele frequency estimation in DNA pools using Pyrosequencing.
Nat Protoc,2006,1:2573-2582
|
CSCD被引
6
次
|
|
|
|
|
16.
Gruber JD. Estimation of single nucleotide polymorphism allele frequency in DNA pools by using Pyrosequencing.
Hum Genet,2002,110:395-401
|
CSCD被引
7
次
|
|
|
|
|
17.
Ni Z. Effect of salt loading on nitric oxide synthase expression in nomrotensive rats.
Am J Hypertens,2000,14:155-163
|
CSCD被引
1
次
|
|
|
|
|
18.
Lee MY. Genomic changes in regenerated porcine coronary arterial endothelial cells.
Arterioscler Thromb Vasc Biol,2007,27:2443-2449
|
CSCD被引
3
次
|
|
|
|
|
19.
Voetsch B. Promoter polymorphisms in the plasma glutathione peroxidase(GPx-3)gene:a novel risk factor for arterial ischemic stroke among young adults and children.
Stroke,2007,38:41-49
|
CSCD被引
6
次
|
|
|
|
|
20.
Voetsch B. Role of promoter polymorphisms in the plasma glutathione peroxidase(GPx-3)gene as a risk factor for cerebral venous thrombosis.
Stroke,2008,39:303-307
|
CSCD被引
8
次
|
|
|
|
|
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