丰富环境对野生小家鼠和昆明小鼠空间学习记忆能力的影响
Differential effects of early environmental enrichment on spatial learning and memory of wild house mouse and Kunming mouse
查看参考文献12篇
|
文摘
|
目的比较丰富环境对野生小家鼠和驯化小鼠空间学习记忆能力的影响。方法为控制丰富环境,实验选用了野生小家鼠F1代。断奶后,将野生小家鼠Fl代和昆明小鼠(由野生小家鼠驯化而来)随机放入普通环境和丰富环境内饲养,1个月后进行水迷宫实验:野生普通组(n=6)、野生丰富组(n=7)、昆明普通组(n=10)、昆明丰富组(n=10)。结果(1)记忆阶段,早期丰富饲养环境可以显著缩短野生小家鼠找到站台的潜伏期[普通环境(39.5±3.8)s;丰富环境(25.2±4.5)s;F(1,22)=8.115,P<0.01],但是对昆明小鼠没有显著影响[普通环境(8.5±2.4)s;丰富环境(7.5±1.7)s;F(1,36)=0.149,P=0.702];(2)学习阶段,早期丰富饲养环境可以显著缩短野生小家鼠(F(1,132)=15.307,P<0.01)和昆明小鼠(F(1,216)=8.701,P< 0.01)找到站台的潜伏期。结论早期丰富饲养环境可以提高小鼠的空间学习记忆能力,且对野生小家鼠的影响更大。因此,在丰富环境相关研究中,野生动物模型具有更好的效度。 |
|
其他语种文摘
|
Objective To evaluate and compare the effect of early environmental enrichment on spatial learning and memory in wild house mouse and Kunming mouse,one kind of laboratory mouse which evolved from wild house mouse.Methods The wild house mouse Fl generation were employed to control the environmental enrichment.Offspring were weaned on PND22 and housed in usual or rich environment for one month randomly,then engaged the morris maze:house mouse rich environment(n =7),house mouse poor environment(n =6),Kunming mouse rich environment(n = 10),Kunming mouse poor environment(n =10).Results (1)Early environmental enrichment improve the performance of house mouse (poor environment:(39.5 ± 3.8)s; rich environment:(25.2 ±4.5)s; F(1,22)=8.115,P<0.01),but had no effect on that of Kunming mouse in tests of spatial memory (poor environment:(8.5 ±2.4)s; rich environment:(7.5 ± 1.7)s; F(1,36)=0.149,P=0.702).(2)Early environmental enrichment improve the performance of house mouse (F(1,132)= 15.307,P< 0.01)and Kunming mouse (F(1,216)=8.701,P<0.01)in spatial learn session.Conclusion The wild house mouse is more sensitive to the enrich environment than laboratory mouse.Therefore,it has higher validity of model. |
|
来源
|
中华行为医学与脑科学杂志
,2011,20(7):624-626 【扩展库】
|
|
关键词
|
丰富环境
;
野生小家鼠
;
昆明小鼠
;
水迷宫
;
学习记忆
|
|
地址
|
1.
中国科学院心理研究所, 中国科学院心理健康重点实验室, 北京, 100101
2.
北京市中关村中学
|
|
语种
|
中文 |
|
文献类型
|
研究性论文 |
|
ISSN
|
1674-6554 |
|
学科
|
预防医学、卫生学 |
|
基金
|
国家自然科学基金项目
;
国家973计划
|
|
文献收藏号
|
CSCD:4281262
|
参考文献 共
12
共1页
|
|
1.
刘珊珊. 丰富环境和艾司西酞普兰对母婴分离大鼠成年早期抑郁样行为和学习记忆的影响.
中华行为医学与脑科学杂志,2010,19:385-388
|
CSCD被引
4
次
|
|
|
|
|
2.
Frick KM. Effects of environmental enrichment on spatial memory and neurochemistry in middle-aged mice.
Learn Memory,2003,10:187-198
|
CSCD被引
6
次
|
|
|
|
|
3.
Leggio MG. Environmental enrichment promotes improved spatial abilities and enhanced dendritic growth in the rat.
Behav Brain Res,2005,163:78-90
|
CSCD被引
12
次
|
|
|
|
|
4.
Augustsson H. Exploration and risk assessment:a comparative study of male house mice(Mus musculus musculus)and two laboratory strains.
Physiol Behav,2004,81:685-698
|
CSCD被引
2
次
|
|
|
|
|
5.
Stuermer IW. Early experience and domestication affect auditory discrimination learning,open field behaviour and brain size in wild Mongolian gerbils and domesticated laboratory gerbils(Meriones unguiculatus forma domestica).
Behav Brain Res,2006,173:11-21
|
CSCD被引
2
次
|
|
|
|
|
6.
Pleskacheva MG. Hippocampal mossy fibers and swimming navigation learning in two vole species occupying different habitats.
Hippocampus,2000,10:17-30
|
CSCD被引
1
次
|
|
|
|
|
7.
Huck UW. Differential effects of environmental enrichment on the open-field behavior of wild and domestic Norway rats.
J Comp Psychol,1975,89:892-898
|
CSCD被引
1
次
|
|
|
|
|
8.
Wade CM. The mosaic structure of variation in the laboratory mouse genome.
Nature,2002,420:574-578
|
CSCD被引
3
次
|
|
|
|
|
9.
Rampon C. Effects of environmental enrichment on gene expression in the brain.
Proc Natl Acad Sci USA,2000,97:12880-12884
|
CSCD被引
12
次
|
|
|
|
|
10.
Powell SB. Development of spontaneous stereotyped behavior in deer mice:effects of early and late exposure to a more complex environment.
Dev Psychobiol,2000,37:100-108
|
CSCD被引
1
次
|
|
|
|
|
11.
Hadley C. Spontaneous stereotypy and environmental enrichment in deer mice(Peromyscus maniculatus):reversibility of experience.
Appi Anim Behav Sci,2006,97:312-322
|
CSCD被引
1
次
|
|
|
|
|
12.
Schrijver NC. Dissociable effects of isolation rearing and environmental enrichment on exploration,spatial learning and HPA activity in adult rats.
Pharmacol Biochem Behav,2002,73:209-224
|
CSCD被引
4
次
|
|
|
|
|
了解气象卫星更多信息，请访问